Structure of PDB 8e89 Chain A

Receptor sequence

>8e89A (length=425) Species: 9606 (Homo sapiens) [Search protein sequence]

GPHMATGQDRVVALVDMDCFFVQVEQRQNPHLRNKPCAVVQYKSWKGGGI
IAVSYEARAFGVTRSMWADDAKKLCPDLLLAQVRESRGKANLTKYREASV
EVMEIMSRFAVIERASIDEAYVDLTSAVQERLQKLQGQPISADLLPSTYI
EGLPQGQKEGMRKQGLFQWLDSLQIDNLTSPDLQLTVGAVIVEEMRAAIE
RETGFQCSAGISHNKVLAKLACGLNKPNRQTLVSHGSVPQLFSQMPIRKI
RSLGGKLGASVIEILGIEYMGELTQFTESQLQSHFGEKNGSWLYAMCRGI
EHDPVKPRQLPKTIGCSKNFPGKTALATREQVQWWLLQLAQELEERLTKD
RNDNDRVATQLVVSIRVQGDKRLSSLRRCCALTRYDAHKMSHDAFTVIKN
CNTSGTEWSPPLTMLFLCATKFSAS

3D structure

PDB

8e89 Primer terminal ribonucleotide alters the active site dynamics of DNA polymerase eta and reduces DNA synthesis fidelity.

Chain

Resolution

2.2 Å

3D
structure

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Enzymatic activity

Enzyme Commision number

2.7.7.7: DNA-directed DNA polymerase.

Interaction with ligand

Site #	Ligand	Ligand chain	Binding residues on receptor (original residue number in PDB)	Binding residues on receptor (residue number reindexed from 1)	Binding affinity
BS01	dna	A	Q38 Y39 W42 R61 S62 K86 R93 P316 K317 T318 G320 S322 K323 N324 P326 G327 R351	Q41 Y42 W45 R64 S65 K89 R96 P311 K312 T313 G315 S317 K318 N319 P321 G322 R346
BS02	dna	A	R61 K224 S257 G259 G260 K261 L262 R377 L381 R382 R383 C384	R64 K219 S252 G254 G255 K256 L257 R372 L376 R377 R378 C379

Gene Ontology

	Molecular Function
GO:0003684	damaged DNA binding

	Biological Process
GO:0006281	DNA repair

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Molecular Function

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Biological Process

External links

PDB	RCSB:8e89, PDBe:8e89, PDBj:8e89
PDBsum	8e89
PubMed	36702254
UniProt	Q9Y253\|POLH_HUMAN DNA polymerase eta (Gene Name=POLH)

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