Structure of PDB 8e6v Chain A

Receptor sequence
>8e6vA (length=707) Species: 9606 (Homo sapiens) [Search protein sequence]
SSWIPENIKKKECVYFVESSKLSDAGKVVCQCGYTHEQHLEEATKPHTFQ
GTQWDPKKHVQEMPTDAFGDIVFTGLSQKVKKYVRVSQDTPSSVIYHLMT
QHWGLDVPNLLISVTGGAKNFNMKPRLKSIFRRGLVKVAQTTGAWIITGG
SHTGVMKQVGEAVRDFSLSSSYKEGELITIGVATWGTVHRREGLIHPTGS
FPAEYILDEDGQGNLTCLDSNHSHFILVDDGTHGQYGVEIPLRTRLEKFI
SEQTKERGGVAIKIPIVCVVLEGGPGTLHTIDNATTNGTPCVVVEGSGRV
ADVIAQVANLPVSDITISLIQQKLSVFFQEMFETFTESRIVEWTKKIQDI
VRRRQLLTVFREGKDGQQDVDVAILQALLKASRSQDHFGHENWDHQLKLA
VAWNRVDIARSEIFMDEWQWKPSDLHPTMTAALISNKPEFVKLFLENGVQ
LKGDSYHVNARHLLYPNCPVTRFPVPNEKVPWETEFLIYDPPFYTALEPL
STIQYNVVDGLRDRRSFHGPYTVQAGLPLNPMGRTGLRGRGSLSCFGPNH
TLYPMVTRWRRNEDGAICRKSIKKMLEVLVVKLPLSEHWALPGGSREPGE
MLPRKLKRILRQEHWPSFENLLKCGMEVYKGYMDDPRNTDNAWIETVAVS
VHFQDQNDVELNRLNSNLHACDSGASIRWQVVDRRIPLYANHKTLLQKAA
AEFGAHY
3D structure
PDB8e6v A unified mechanism for human TRPM2 activation, desensitization and inhibition
ChainA
Resolution3.3 Å
3D
structure
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Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 APR A T174 G175 A177 K178 M215 T275 Y295 E298 G332 G333 P334 G335 R358 T115 G116 A118 K119 M156 T216 Y236 E239 G273 G274 P275 G276 R299
BS02 APR A D1431 P1432 R1433 Y1485 N1487 D635 P636 R637 Y689 N691
BS03 ZN A C72 C89 C91 H98 C13 C30 C32 H39
External links
PDB RCSB:8e6v, PDBe:8e6v, PDBj:8e6v
PDBsum8e6v
PubMed
UniProtO94759|TRPM2_HUMAN Transient receptor potential cation channel subfamily M member 2 (Gene Name=TRPM2)

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