Structure of PDB 8e60 Chain A

Receptor sequence
>8e60A (length=393) Species: 1299 (Deinococcus radiodurans) [Search protein sequence]
LGPAVIASIAYMDPGNFATNIEGGARYGYSLLWVILAANLMAMVIQNLSA
NLGIASGRNLPELIRERWPRPLVWFYWIQAELVAMATDLAEFLGAALAIQ
LLTGLPMFWGAVVTGVVTFWLLNLQKRGTRPLELAVGAFVLMIGVAYLVQ
VVLARPDLAAVGAGFVPRLQGPGSAYLAVGIIGATVMPHVIYLHSALTQG
RIQTDTTEEKRRLVRLNRVDVIAAMGLAGLINMSMLAVAAATFHGKNVEN
AGDLTTAYQTLTPLLGPAASVLFAVALLASGLSSSAVGTMAGDVIMQGFM
GFHIPLWLRRLITMLPAFIVILLGMDPSSVLILSQVILCFGVPFALVPLL
LFTARRDVMGALVTRRSFTVIGWVIAVIIIALNGYLLWELLGG
3D structure
PDB8e60 High-resolution structures with bound Mn 2+ and Cd 2+ map the metal import pathway in an Nramp transporter.
ChainA
Resolution2.38 Å
3D
structure
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Enzymatic activity
Enzyme Commision number ?
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 MN A A53 Y54 D56 N59 A227 M230 A10 Y11 D13 N16 A184 M187
BS02 MN A D296 D369 D253 D326
Gene Ontology
Molecular Function
GO:0005384 manganese ion transmembrane transporter activity
GO:0015086 cadmium ion transmembrane transporter activity
GO:0015293 symporter activity
GO:0046872 metal ion binding
GO:0046873 metal ion transmembrane transporter activity
Biological Process
GO:0006811 monoatomic ion transport
GO:0006828 manganese ion transport
GO:0030001 metal ion transport
GO:0034755 iron ion transmembrane transport
GO:0070574 cadmium ion transmembrane transport
GO:0071421 manganese ion transmembrane transport
Cellular Component
GO:0005886 plasma membrane
GO:0016020 membrane

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External links
PDB RCSB:8e60, PDBe:8e60, PDBj:8e60
PDBsum8e60
PubMed37039477
UniProtQ9RTP8|MNTH_DEIRA Divalent metal cation transporter MntH (Gene Name=mntH)

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