Structure of PDB 8e5a Chain A

Receptor sequence
>8e5aA (length=1230) Species: 9606 (Homo sapiens) [Search protein sequence]
SIVEWKPFDIFILLAIFANCVALAIYIPFPEDDSNSTNHNLEKVEYAFLI
IFTVETFLKIIYVRNGWNLLDFVIVIVGLFSVILEQLTDVKALRAFRVLR
PLRLVSGVPSLQVVLNSIIKAMVPLLHIALLVLFVIIIYAIIGLELFIGK
MHKTCFFADSDIVAEEDPAPCAFSGNGRQCTANGTECRSGWVGPNGGITN
FDNFAFAMLTVFQCITMEGWTDVLYWMNDAMGFELPWVYFVSLVIFGSFF
VLNLVLGVLSGEFSKEREKAKARGDFQKLREKQQLEEDLKGYLDWITQAE
DCRAAVKSVTFYWLVIVLVFLNTLTISSEHYNQPDWLTQIQDIANKVLLA
LFTCEMLVKMYSLGLQAYFVSLFNRFDCFVVCGGITETILVELEIMSPLG
ISVFRCVRLLRIFKVTRHWTSLSNLVASLLNSMKSIASLLLLLFLFIIIF
SLLGMQLFGGKFNFDETQTKRSTFDNFPQALLTVFQILTGEDWNAVMYDG
IMAYGGPSSSGMIVCIYFIILFICGNYILLNVFLAIAVDNLADAESLNTA
QKEEAEEKIRVGCHKLINHHIFTNLILVFIMLSSAALAAEDPIRSHSFRN
TILGYFDYAFTAIFTVEILLKMTTFGNYFNLLDMLVVGVSLVSFVVKILR
VLRVLRPLRAINRAKGLKHVVQCVFVAIRTIGNIMIVTTLLQFMFACIGV
QLFKGKFYRCTDEAKSNPEECRGLFILYKDGDVDSPVVRERIWQNSDFNF
DNVLSAMMALFTVSTFEGWPALLYKAIDSNGENIGPIYNHRVEISIFFII
YIIIVAFFMMNIFVGFVIVTFQEQGEKEYKNCELDKNQRQCVEYALKARP
LRRYIPKNPYQYKFWYVVNSSPFEYMMFVLIMLNTLCLAMQHYEQSKMFN
DAMDILNMVFTGVFTVEMVLKVIAFKPKGYFSDAWNTFDSLIVIGSIIDV
ALSESITFFRLFRVMRLVKLLSRGEGIRTLLWTFIKSFQALPYVALLIAM
LFFIYAVIGMQMFGKVAMRDNNQINRNNNFQTFPQAVLLLFRCATGEAWQ
EIMLACLPGKLCDPESDYNPGEEYTCGSNFAIVYFISFYMLCAFLIINLF
VAVIMDNFDYLTRDWSILGPHHLDEFKRIWSEYDPEAKGRIKHLDVVTLL
RRIQPPLGFGKLCPHRVACKRLVAMNMPLNSDGTVMFNATLFALVRTALK
IKTEGNLEQANEELRAVIKKIWKKTSMKLL
3D structure
PDB8e5a Structural basis for the severe adverse interaction of sofosbuvir and amiodarone on L-type Ca v channels.
ChainA
Resolution3.3 Å
3D
structure
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Enzymatic activity
Enzyme Commision number ?
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 CA A E364 E705 E1101 E218 E491 E767
Gene Ontology
Molecular Function
GO:0005216 monoatomic ion channel activity
GO:0005245 voltage-gated calcium channel activity
GO:0005262 calcium channel activity
GO:0005515 protein binding
GO:0008331 high voltage-gated calcium channel activity
GO:0030506 ankyrin binding
GO:0046872 metal ion binding
GO:0051393 alpha-actinin binding
GO:0086007 voltage-gated calcium channel activity involved in cardiac muscle cell action potential
GO:0086059 voltage-gated calcium channel activity involved SA node cell action potential
Biological Process
GO:0006811 monoatomic ion transport
GO:0006816 calcium ion transport
GO:0007188 adenylate cyclase-modulating G protein-coupled receptor signaling pathway
GO:0007605 sensory perception of sound
GO:0045762 positive regulation of adenylate cyclase activity
GO:0051928 positive regulation of calcium ion transport
GO:0055085 transmembrane transport
GO:0060372 regulation of atrial cardiac muscle cell membrane repolarization
GO:0070509 calcium ion import
GO:0070588 calcium ion transmembrane transport
GO:0086002 cardiac muscle cell action potential involved in contraction
GO:0086012 membrane depolarization during cardiac muscle cell action potential
GO:0086046 membrane depolarization during SA node cell action potential
GO:0086091 regulation of heart rate by cardiac conduction
GO:0098703 calcium ion import across plasma membrane
GO:1901016 regulation of potassium ion transmembrane transporter activity
GO:1901379 regulation of potassium ion transmembrane transport
Cellular Component
GO:0005886 plasma membrane
GO:0005891 voltage-gated calcium channel complex
GO:0016020 membrane
GO:0030018 Z disc
GO:0034702 monoatomic ion channel complex
GO:1990454 L-type voltage-gated calcium channel complex

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:8e5a, PDBe:8e5a, PDBj:8e5a
PDBsum8e5a
PubMed36417914
UniProtQ01668|CAC1D_HUMAN Voltage-dependent L-type calcium channel subunit alpha-1D (Gene Name=CACNA1D)

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