Structure of PDB 8e57 Chain A

Receptor sequence
>8e57A (length=1105) Species: 9986 (Oryctolagus cuniculus) [Search protein sequence]
QNPLRKACISIVEWKPFETIILLTIFANCVALAVYLPMPEDDNNSLNLGL
EKLEYFFLTVFSIEAAMKIIAYSGWNVLDFIIVFLGVFTAILEQVNVVKA
LRAFRVLRPLRLVSGVPSLQVVLNSIFKAMLPLFHIALLVLFMVIIYAII
GLELFKGKMHKTCYYIGTDIVATVENEKPSPCARTGSGRPCTINGSECRG
GWPGPNHGITHFDNFGFSMLTVYQCITMEGWTDVLYWVNDAIGNEWPWIY
FVTLILLGSFFILNLVLGVLSGEFTKEREKAKSRVFYWLVILIVALNTLS
IASEHHNQPLWLTHLQDIANRVLLSLFTIEMLLKMYGLGLRQYFMSIFNR
FDCFVVCSGILELLLVESGAMTPLGISVLRCIRLLRLFKITKYWTSLSNL
VASLLNSIRSIASLLLLLFLFIIIFALLGMQLFGGRYDFEDTEVRRSNFD
NFPQALISVFQVLTGEDWNSVMYNGIMAYGGPSYPGVLVCIYFIILFVCG
NYILLNVFLAIAVDNLAEAESLTSAVNATWFTNFILLFILLSSAALAAED
PIRAESVRNQILGYFDIAFTSVFTVEIVLKMTTYGYFNILDLLVVAVSLI
SMVVKILRVLRVLRPLRAINRAKGLKHVVQCVFVAIRTIGNIVLVTTLLQ
FMFACIGVQLFKGKFFSCNDLSKMTEEECRGYYYVYKDGDPTQMELRPRQ
WIHNDFHFDNVLSAMMSLFTVSTFEGWPQLLYRAIDSNEEDMGPVYNNRV
EMAIFFIIYIILIAFFMMNIFVGFVIVTFQEQGDKNQRQCVQYALKARPL
RCYIPKNPYQYQVWYVVTSSYFEYLMFALIMLNTICLGMQHYHHISDILN
VAFTIIFTLEMILKLLAFKARGYFGDPWNVFDFLIVIGSIIDVILSEIDT
FLSAFFRLFRVMRLIKLLSRAEGVRTLLWTFIKSFQALPYVALLIVMLFF
IYAVIGMQMFGKIALVDGTQINRNNNFQTFPQAVLLLFRCATGEAWQEIL
LACSYGKLCDPESDYAPGEEYTCGTNFAYYYFISFYMLCAFLIINLFVAV
IMDNFDYLTRDWSILGPHHLDEFKAIWAEYDPEAKGRIKHLDVVTLLRRI
QPPLG
3D structure
PDB8e57 Structural basis for the severe adverse interaction of sofosbuvir and amiodarone on L-type Ca v channels.
ChainA
Resolution2.8 Å
3D
structure
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Enzymatic activity
Enzyme Commision number ?
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 CA A E292 E614 E1014 G1322 E229 E466 E725 G993
BS02 BBI A V932 S1011 T1012 M1057 Y1365 L1367 V643 S722 T723 M768 Y1036 L1038
BS03 WFR A L326 N649 L653 F1054 I1372 L263 N501 L505 F765 I1043
Gene Ontology
Molecular Function
GO:0005216 monoatomic ion channel activity
GO:0005245 voltage-gated calcium channel activity
GO:0005262 calcium channel activity
GO:0005515 protein binding
GO:0005516 calmodulin binding
GO:0008331 high voltage-gated calcium channel activity
GO:0044325 transmembrane transporter binding
GO:0046872 metal ion binding
Biological Process
GO:0006811 monoatomic ion transport
GO:0006936 muscle contraction
GO:0045933 positive regulation of muscle contraction
GO:0051209 release of sequestered calcium ion into cytosol
GO:0055085 transmembrane transport
GO:0060314 regulation of ryanodine-sensitive calcium-release channel activity
GO:0070588 calcium ion transmembrane transport
GO:0071313 cellular response to caffeine
GO:0098703 calcium ion import across plasma membrane
Cellular Component
GO:0005886 plasma membrane
GO:0005891 voltage-gated calcium channel complex
GO:0016020 membrane
GO:0030315 T-tubule
GO:0034702 monoatomic ion channel complex
GO:1990454 L-type voltage-gated calcium channel complex

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:8e57, PDBe:8e57, PDBj:8e57
PDBsum8e57
PubMed36417914
UniProtP07293|CAC1S_RABIT Voltage-dependent L-type calcium channel subunit alpha-1S (Gene Name=CACNA1S)

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