Structure of PDB 8e50 Chain A

Receptor sequence
>8e50A (length=651) Species: 9606 (Homo sapiens) [Search protein sequence]
GLRNVIYINETHTRHRGWLARRLSYVLFIQERDVHKGMFATNVTENVLNS
SRVQEAIAEVAAELNPQSKAVNKVKKKAKRILQEMVATVSPAMIRLTGWV
LLKLFNSFFWNIQIHKGQLEMVKAATETNLPLLFLPVHRSHIDYLLLTFI
LFCHNIKAPYIASGNNLNIPIFSTLIHKLGGFFIRRRLDETPDGRKDVLY
RALLHGHIVELLRQQQFLEIFLEGTRSRSGKTSCARAGLLSVVVDTLSTN
VIPDILIIPVGISYDRIIEGHYNGEQLGWSVARGVIRMLRKNYGCVRVDF
AQPFSLKEYLESQSQKPVSALLSLEQALLPAILPTDESLRRRLIANLAEH
ILFTASKSCAIMSTHIVACLLLYRHRQGIDLSTLVEDFFVMKEEVLARDF
DLGFSGNSEDVVMHAIQLLGNCVTITHTSRNDEFFITPSTTVPSVFELNF
YSNGVLHVFIMEAIIACSLYAVLNLISQEQLVRKAASLCYLLSNEGTISL
PCQTFYQVCHETVGKFIQYGILTVADCYLKVSQSKEHQQFITFLQRLLGP
LLEAYSSAAIFVHNFSGPVPEPEYLQKLHKYLITRTERNVAVYAESATYC
LVKNAVKMFKDIGVFKETKQKRVSVLELSSTFLPQCNRQKLLEYILSFVV
L
3D structure
PDB8e50 Structural basis of the acyl-transfer mechanism of human GPAT1.
ChainA
Resolution3.67 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 2.3.1.15: glycerol-3-phosphate 1-O-acyltransferase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 COA A R278 L280 K288 F313 R328 A329 G330 R462 R186 L188 K196 F221 R236 A237 G238 R341
BS02 NKO A G190 H230 Y236 T240 F244 S255 L259 I268 T317 R318 G98 H138 Y144 T148 F152 S163 L167 I176 T225 R226
Gene Ontology
Molecular Function
GO:0004366 glycerol-3-phosphate O-acyltransferase activity
GO:0005515 protein binding
GO:0008374 O-acyltransferase activity
GO:0016746 acyltransferase activity
Biological Process
GO:0001817 regulation of cytokine production
GO:0006072 glycerol-3-phosphate metabolic process
GO:0006631 fatty acid metabolic process
GO:0006637 acyl-CoA metabolic process
GO:0006641 triglyceride metabolic process
GO:0006650 glycerophospholipid metabolic process
GO:0006651 diacylglycerol biosynthetic process
GO:0006654 phosphatidic acid biosynthetic process
GO:0006655 phosphatidylglycerol biosynthetic process
GO:0006924 activation-induced cell death of T cells
GO:0008654 phospholipid biosynthetic process
GO:0009749 response to glucose
GO:0016024 CDP-diacylglycerol biosynthetic process
GO:0019432 triglyceride biosynthetic process
GO:0040018 positive regulation of multicellular organism growth
GO:0042104 positive regulation of activated T cell proliferation
GO:0044255 cellular lipid metabolic process
GO:0050798 activated T cell proliferation
GO:0051607 defense response to virus
GO:0055089 fatty acid homeostasis
GO:0055091 phospholipid homeostasis
GO:0070236 negative regulation of activation-induced cell death of T cells
Cellular Component
GO:0005739 mitochondrion
GO:0005741 mitochondrial outer membrane
GO:0005886 plasma membrane
GO:0031966 mitochondrial membrane

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:8e50, PDBe:8e50, PDBj:8e50
PDBsum8e50
PubMed36522428
UniProtQ9HCL2|GPAT1_HUMAN Glycerol-3-phosphate acyltransferase 1, mitochondrial (Gene Name=GPAM)

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