Structure of PDB 8e4y Chain A

Receptor sequence
>8e4yA (length=651) Species: 9606 (Homo sapiens) [Search protein sequence]
GLRNVIYINETHTRHRGWLARRLSYVLFIQERDVHKGMFATNVTENVLNS
SRVQEAIAEVAAELNPQSKAVNKVKKKAKRILQEMVATVSPAMIRLTGWV
LLKLFNSFFWNIQIHKGQLEMVKAATETNLPLLFLPVHRSHIDYLLLTFI
LFCHNIKAPYIASGNNLNIPIFSTLIHKLGGFFIRRRLDETPDGRKDVLY
RALLHGHIVELLRQQQFLEIFLEGTRSRSGKTSCARAGLLSVVVDTLSTN
VIPDILIIPVGISYDRIIEGHYNGEQLGWSVARGVIRMLRKNYGCVRVDF
AQPFSLKEYLESQSQKPVSALLSLEQALLPAILPTDESLRRRLIANLAEH
ILFTASKSCAIMSTHIVACLLLYRHRQGIDLSTLVEDFFVMKEEVLARDF
DLGFSGNSEDVVMHAIQLLGNCVTITHTSRNDEFFITPSTTVPSVFELNF
YSNGVLHVFIMEAIIACSLYAVLNLISQEQLVRKAASLCYLLSNEGTISL
PCQTFYQVCHETVGKFIQYGILTVADCYLKVSQSKEHQQFITFLQRLLGP
LLEAYSSAAIFVHNFSGPVPEPEYLQKLHKYLITRTERNVAVYAESATYC
LVKNAVKMFKDIGVFKETKQKRVSVLELSSTFLPQCNRQKLLEYILSFVV
L
3D structure
PDB8e4y Structural basis of the acyl-transfer mechanism of human GPAT1.
ChainA
Resolution3.4 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 2.3.1.15: glycerol-3-phosphate 1-O-acyltransferase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 UKL A Y236 T240 S255 L259 R278 R279 K288 R293 G316 R328 A329 G330 S333 R462 Y144 T148 S163 L167 R186 R187 K196 R201 G224 R236 A237 G238 S241 R341
Gene Ontology
Molecular Function
GO:0004366 glycerol-3-phosphate O-acyltransferase activity
GO:0005515 protein binding
GO:0008374 O-acyltransferase activity
GO:0016746 acyltransferase activity
Biological Process
GO:0001817 regulation of cytokine production
GO:0006072 glycerol-3-phosphate metabolic process
GO:0006631 fatty acid metabolic process
GO:0006637 acyl-CoA metabolic process
GO:0006641 triglyceride metabolic process
GO:0006650 glycerophospholipid metabolic process
GO:0006651 diacylglycerol biosynthetic process
GO:0006654 phosphatidic acid biosynthetic process
GO:0006655 phosphatidylglycerol biosynthetic process
GO:0006924 activation-induced cell death of T cells
GO:0008654 phospholipid biosynthetic process
GO:0009749 response to glucose
GO:0016024 CDP-diacylglycerol biosynthetic process
GO:0019432 triglyceride biosynthetic process
GO:0040018 positive regulation of multicellular organism growth
GO:0042104 positive regulation of activated T cell proliferation
GO:0044255 cellular lipid metabolic process
GO:0050798 activated T cell proliferation
GO:0051607 defense response to virus
GO:0055089 fatty acid homeostasis
GO:0055091 phospholipid homeostasis
GO:0070236 negative regulation of activation-induced cell death of T cells
Cellular Component
GO:0005739 mitochondrion
GO:0005741 mitochondrial outer membrane
GO:0005886 plasma membrane
GO:0031966 mitochondrial membrane

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:8e4y, PDBe:8e4y, PDBj:8e4y
PDBsum8e4y
PubMed36522428
UniProtQ9HCL2|GPAT1_HUMAN Glycerol-3-phosphate acyltransferase 1, mitochondrial (Gene Name=GPAM)

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