Structure of PDB 8e4t Chain A

Receptor sequence
>8e4tA (length=268) Species: 81824 (Monosiga brevicollis) [Search protein sequence]
SKEPRELNREWLIVLSELGQGAFGIVYEASLSEPKAPEIQVAAKSLRKDA
MDNEREELLEEALVMAQMEHANVVGLIGVITKGRPIYVVLEHMRNGSLKD
YVMNKTCTPAQQVTWSRQVASGMAHIHSLGFIHRDLAARNVLLSASLTAK
VADFGLARESTDSRGGNVPVRWTAPEALEDNIFSEKSDVWAFGVLMYEVY
TKAAMPYTGWNNQRVWIEVTNGFRLPCPADCPLPVFKIMSMCWLHDRHER
PSFETLVKALAALETDSD
3D structure
PDB8e4t Crystal structure of the kinase domain of a receptor tyrosine kinase from a choanoflagellate, Monosiga brevicollis.
ChainA
Resolution1.95 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 2.7.10.1: receptor protein-tyrosine kinase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 STU A V1557 A1573 K1575 H1623 M1624 G1627 R1670 L1673 V26 A42 K44 H92 M93 G96 R139 L142
BS02 STU A G1701 G1702 V1706 N1748 G165 G166 V170 N212
Gene Ontology
Molecular Function
GO:0004672 protein kinase activity
GO:0004713 protein tyrosine kinase activity
GO:0005524 ATP binding
Biological Process
GO:0006468 protein phosphorylation

View graph for
Molecular Function
View graph for
Biological Process
External links
PDB RCSB:8e4t, PDBe:8e4t, PDBj:8e4t
PDBsum8e4t
PubMed37310965
UniProtA9VBW0

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