Structure of PDB 8e4m Chain A

Receptor sequence
>8e4mA (length=881) Species: 10090 (Mus musculus) [Search protein sequence]
DLVNFIQANFDAFGDIQGKYLRLSCDTDSETLYELLTQHWHLKTPNLVIS
NFALKPRMRKIFSRLIYIAQSKGAWILTGGTHYGLMKYIGEVVRDNTISE
NIVAIGIAAWGMVSNRDTLSAQYIMYILDNNHTHLLLVDNGTVEAKLRNQ
LEKYISERTSQDSNYGGKIPIVCFAQGGGRETLKAINTSVKSKIPCVVVE
QIADVIASLVTSSMVKEKLVRFLPRTVSRLPEEEIESWIKWLKEILESSH
LLTVIKMEIVSNAISYALYKAFSTNEQDKDNWNGQLKLLLEWNQLDLASD
EIFTNDRRWESADLQEVMFTALIKDRPKFVRLFLENGLNLQKFLTNEVLT
ELFSTHFSTLVYRNLQIAKNSYNDALLTFVWKLVANFRRSTRHPLQALFI
WAILQNKKELSKVIWEQTKGCTLAALGASKLLKTLAKVKNDINAAGESEE
LANEYETRAVELFTECYSNDEDLAEQLLVYSCEAWGGSNCLELAVEATDQ
HFIAQPGVQNFLSKQWYGEISRDTKNWKIILCLFIIPLVGCGLVSFRKKL
LWYYVAFFTSPFVVFSWNVVFYIAFLLLFAYVLLMDFHSVPHTPELILYA
LVFVLFCDEVRQWYMNGVNYFTDLWNVMDTLGLFYFIAGIVFRLHSSNKS
SLYSGRVIFCLDYIIFTLRLIHIFTVSRNLGPKIIMLQRMLIDVFFFLFL
FAVWMVAFGVARQGILRQNEQRWRWIFRSVIYEPYLAMFGQVPSDVDSTP
EWITIPLVCIYMLSTNILLVNLLVAMFGYTVGIVQENNDQVWKFQRYFLV
QEYCNRLNIPFPFVVFAYFYMVVNEDNETLAWEGVMKENYLVKINTKAND
NSEEMRHRFRQLDSKLNDLKSLLKEIANNIK
3D structure
PDB8e4m Activation mechanism of the mouse cold-sensing TRPM8 channel by cooling agonist and PIP 2.
ChainA
Resolution3.44 Å
3D
structure
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Enzymatic activity
Enzyme Commision number ?
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 PIO A S679 R688 F735 S739 V743 V849 S850 S513 R522 F562 S566 V570 V676 S677
BS02 ULO A L778 L806 F839 R842 I846 F1013 L605 L633 F666 R669 I673 F811
BS03 CA A Q785 N799 Q612 N626
Gene Ontology
Molecular Function
GO:0005216 monoatomic ion channel activity
GO:0005261 monoatomic cation channel activity
GO:0005262 calcium channel activity
GO:0005515 protein binding
GO:0042802 identical protein binding
Biological Process
GO:0006811 monoatomic ion transport
GO:0006816 calcium ion transport
GO:0006874 intracellular calcium ion homeostasis
GO:0009266 response to temperature stimulus
GO:0009409 response to cold
GO:0034220 monoatomic ion transmembrane transport
GO:0050955 thermoception
GO:0055085 transmembrane transport
GO:0070588 calcium ion transmembrane transport
GO:0120162 positive regulation of cold-induced thermogenesis
Cellular Component
GO:0005886 plasma membrane
GO:0009897 external side of plasma membrane
GO:0016020 membrane
GO:0044853 plasma membrane raft
GO:0045121 membrane raft

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:8e4m, PDBe:8e4m, PDBj:8e4m
PDBsum8e4m
PubMed36227998
UniProtQ8R4D5|TRPM8_MOUSE Transient receptor potential cation channel subfamily M member 8 (Gene Name=Trpm8)

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