Structure of PDB 8e4l Chain A

Receptor sequence
>8e4lA (length=898) Species: 10090 (Mus musculus) [Search protein sequence]
DLVNFIQANFKDAFGDIQFGKYLRLSCDTDSETLYELLTQHWHLKTPNLV
ISVTGGAKNFALKPRMRKIFSRLIYIAQSKGAWILTGGTHYGLMKYIGEV
VRDNTISENIVAIGIAAWGMVSNRDTLFSAQYIMLYILDNNHTHLLLVDN
GCHGHPTVEAKLRNQLEKYISERTSQDSNYGGKIPIVCFAQGGGRETLKA
INTSVKSKIPCVVVEGSGQIADVIASLVEVLTSSMVKEKLVRFLPRTVSR
LPEEEIESWIKWLKEILESSHLLTVIKMEEAGDEIVSNAISYALYKAFST
NEQDKDNWNGQLKLLLEWNQLDLASDEIFTNDRRWESADLQEVMFTALIK
DRPKFVRLFLENGLNLQKFLTNEVLTELFSTHFSTLVYRNLQIAKNSYND
ALLTFVWKLVANFRRSLTTRHPLQALFIWAILQNKKELSKVIWEQTKGCT
LAALGASKLLKTLAKVKNDINAAGESEELANEYETRAVELFTECYSNDED
LAEQLLVYSCEAWGGSNCLELAVEATDQHFIAQPGVQNFLSKQWYGEISR
DTKNWKIILCLFIIPWYYVAFFTSPFVVFSWNVVFYIAFLLLFAYVLLMD
FHSVPHTPELILYALVFVLFCDEVRQWYMNGVNYFTDLWNVMDTLGLFYF
IAGIVFRLHSSNKSSLYSGRVIFCLDYIIFTLRLIHIFTVSRNLGPKIIM
LQRMLIDVFFFLFLFAVWMVAFGVARQGILRQNEQRWRWIFRSVIYEPYL
AMFGQVPSDVDSTTRFPEWITIPLVCIYMLSTNILLVNLLVAMFGYTVGI
VQENNDQVWKFQRYFLVQEYCNRLNIPFPFVVFAYFYMVVKKCNETLAWE
GVMKENYLVKINTKANDNSEEMRHRFRQLDSKLNDLKSLLKEIANNIK
3D structure
PDB8e4l Activation mechanism of the mouse cold-sensing TRPM8 channel by cooling agonist and PIP 2.
ChainA
Resolution3.32 Å
3D
structure
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Enzymatic activity
Enzyme Commision number ?
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 CA A E782 Q785 N799 E623 Q626 N640
BS02 UL9 A W798 Q861 W639 Q702
BS03 ULO A Y745 D802 F839 R842 F1013 Y586 D643 F680 R683 F828
BS04 PIO A S679 R688 F735 S850 R851 R998 S541 R550 F576 S691 R692 R813
Gene Ontology
Molecular Function
GO:0005216 monoatomic ion channel activity
GO:0005261 monoatomic cation channel activity
GO:0005262 calcium channel activity
GO:0005515 protein binding
GO:0042802 identical protein binding
Biological Process
GO:0006811 monoatomic ion transport
GO:0006816 calcium ion transport
GO:0006874 intracellular calcium ion homeostasis
GO:0009266 response to temperature stimulus
GO:0009409 response to cold
GO:0034220 monoatomic ion transmembrane transport
GO:0050955 thermoception
GO:0055085 transmembrane transport
GO:0070588 calcium ion transmembrane transport
GO:0120162 positive regulation of cold-induced thermogenesis
Cellular Component
GO:0005886 plasma membrane
GO:0009897 external side of plasma membrane
GO:0016020 membrane
GO:0044853 plasma membrane raft
GO:0045121 membrane raft

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:8e4l, PDBe:8e4l, PDBj:8e4l
PDBsum8e4l
PubMed36227998
UniProtQ8R4D5|TRPM8_MOUSE Transient receptor potential cation channel subfamily M member 8 (Gene Name=Trpm8)

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