Structure of PDB 8e2r Chain A

Receptor sequence
>8e2rA (length=144) Species: 562 (Escherichia coli) [Search protein sequence]
FSHEYWMRHALTLAKRARDEREVPVGAVLVLNNRVIGEGWNRAKGLHDPT
AHAEIMALRQGGLVMQNYRLIDATLYSTFEPCVMCAGAMIHSRIGRVVFG
VRNAKTHAGSLMDVLHHPGMNHRVEITEGILADECAALLCRFFR
3D structure
PDB8e2r Improved cytosine base editors generated from TadA variants.
ChainA
Resolution2.22 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 3.5.4.33: tRNA(adenine(34)) deaminase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 ZN A H57 C87 C90 H52 C82 C85
Gene Ontology
Molecular Function
GO:0003824 catalytic activity
GO:0008251 tRNA-specific adenosine deaminase activity
GO:0008270 zinc ion binding
GO:0016787 hydrolase activity
GO:0042803 protein homodimerization activity
GO:0046872 metal ion binding
GO:0052717 tRNA-specific adenosine-34 deaminase activity
Biological Process
GO:0002100 tRNA wobble adenosine to inosine editing
GO:0006382 adenosine to inosine editing
GO:0008033 tRNA processing

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Molecular Function
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Biological Process
External links
PDB RCSB:8e2r, PDBe:8e2r, PDBj:8e2r
PDBsum8e2r
PubMed36624149
UniProtP68398|TADA_ECOLI tRNA-specific adenosine deaminase (Gene Name=tadA)

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