Structure of PDB 8e23 Chain A

Receptor sequence
>8e23A (length=637) Species: 9606 (Homo sapiens) [Search protein sequence]
SLSIIDVASDQNLFQTFIKEWRCKKRFSISLACEKIRSLTSSKTGFPIKG
CDDTLVVGLAVCWGGRDAYYFSLQKESLDPSLTLKDRMWYLQSCLRKEKE
CSVVIYDFIQSYKILLLSCGISLEQSYEDPKVACWLLDPDSQEPTLHSIV
TSFLPHELPLLEGMETSQGIQSLGLNAGSEHSGRYRASVESILIFNSMNQ
LNSLLQKENLQDVFRKVEMPSQYCLALLELNGIGFSTAECESQKHIMQAK
LDAIETQAYQLAGHSFSFTSSDDIAEVLFLELKLPPNREQFSTSKDVLNK
LKALHPLPGLILEWRRITNAITKVVFPLQREKCLNPFLGMERIYPVSQSH
TATGRITFTEPNIQNVPRDFEIKMFSISMRHAFVPFPGGSILAADYSQLE
LRILAHLSHDRRLIQVLNTGADVFRSIAAEWKMIEPESVGDDLRQQAKQI
CYGIIYGMGAKSLGEQMGIKENDAACYIDSFKSRYTGINQFMTETVKNCK
RDGFVQTILGRRRYLPGIKDNNPYRKAHAERQAINTIVQGSAADIVKIAT
VNIQKQLETFHSTFKSHGHREGMCPIRGGFFILQLHDELLYEVAEEDVVQ
VAQIVKNEMESAVKLSVKLKVKVKIGASWGELKDFDV
3D structure
PDB8e23 Identification of RP-6685 , an Orally Bioavailable Compound that Inhibits the DNA Polymerase Activity of Pol theta.
ChainA
Resolution2.59 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 2.7.7.49: RNA-directed DNA polymerase.
2.7.7.7: DNA-directed DNA polymerase.
3.6.4.12: DNA helicase.
Interaction with ligand
Gene Ontology
Molecular Function
GO:0003676 nucleic acid binding
GO:0003677 DNA binding
GO:0003887 DNA-directed DNA polymerase activity
Biological Process
GO:0006260 DNA replication
GO:0006261 DNA-templated DNA replication

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Molecular Function
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Biological Process
External links
PDB RCSB:8e23, PDBe:8e23, PDBj:8e23
PDBsum8e23
PubMed36126059
UniProtO75417|DPOLQ_HUMAN DNA polymerase theta (Gene Name=POLQ)

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