Structure of PDB 8e1h Chain A

Receptor sequence
>8e1hA (length=332) Species: 4896 (Schizosaccharomyces pombe) [Search protein sequence]
KRNVVGICAMDAKARSKPCRNILNRIIAEGEFEAIVFGDNMILDEAVENW
PACDYLICFYSSGFPLKKAEKYVELRKPFCVNDVVFQELLWDRRLVLNIL
DAIRVSTPQRLICSRDGGPKINKVLEEKLRRKFGIEITEVPTPEVKMLDE
DTLSVDGKIIKKPYVEKPVYGEDHNIYIYFPKSVGGGGRKLFRKVANKSS
DYDPDLCAPRTEGSFIYEEFMNVDNAEDVKVYTVGPHYSHAETRKSPVVD
GIVRRNPHGKEIRFITNLSEEEKNMASKISIAFEQPVCGFDLLRVSGQSY
VIDVNGWSFVKDNNDYYDNAARILKQMFHVAE
3D structure
PDB8e1h Structures of Fission Yeast Inositol Pyrophosphate Kinase Asp1 in Ligand-Free, Substrate-Bound, and Product-Bound States.
ChainA
Resolution1.9 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 2.7.4.24: diphosphoinositol-pentakisphosphate 1-kinase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 ADP A R123 V195 K197 H204 I206 L221 F250 M251 D258 L323 I332 D333 R93 V165 K167 H174 I176 L191 F220 M221 D228 L293 I302 D303
BS02 I7P A K43 R223 K224 R274 R285 K341 K13 R193 K194 R244 R255 K311
BS03 MG A D321 D333 D291 D303
BS04 MG A D333 N335 D303 N305
Gene Ontology
Molecular Function
GO:0000829 diphosphoinositol pentakisphosphate kinase activity

View graph for
Molecular Function
External links
PDB RCSB:8e1h, PDBe:8e1h, PDBj:8e1h
PDBsum8e1h
PubMed36468882
UniProtO74429|VIP1_SCHPO Inositol hexakisphosphate and diphosphoinositol-pentakisphosphate kinase (Gene Name=asp1)

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