Structure of PDB 8dwk Chain A

Receptor sequence

>8dwkA (length=294) Species: 9606 (Homo sapiens)

SLNLDSIIGRLLEVQGSRPGKNVQLTENEIRGLCLKSREIFLSQPILLEL
EAPLKICGDIHGQYYDLLRLFEYGGFPPESNYLFLGDYVDRGKQSLETIC
LLLAYKIKYPENFFLLRGNHECASINRIYGFYDECKRRYNIKLWKTFTDC
FNCLPIAAIVDEKIFCCHGGLSPDLQSMEQIRRIMRPTDVPDQGLLCDLL
WSDPDKDVQGWGENDRGVSFTFGAEVVAKFLHKHDLDLICRAHQVVEDGY
EFFAKRQLVTLFSAPNYCGEFDNAGAMMSVDETLMCSFQILKPA

3D structure

• PDB: 8dwk Inhibitor-3 inhibits Protein Phosphatase 1 via a metal binding dynamic protein-protein interaction.
• Chain: A
• Resolution: 2.5 Å

Enzymatic activity

• Enzyme Commision number: 3.1.3.16: protein-serine/threonine phosphatase.

Interaction with ligand

Site #	Ligand	Ligand chain	Binding residues on receptor (original residue number in PDB)	Binding residues on receptor (residue number reindexed from 1)	Binding affinity
BS01	peptide	A	E54 L55 E56 N86 E116 N117 F119 D208 N219 D220 R221 D242 V250 E252 D253 Y255 E256 F257 A259 K260 R261 C273 F276 E287 L289 M290 C291 S292 F293	E49 L50 E51 N81 E111 N112 F114 D203 N214 D215 R216 D237 V245 E247 D248 Y250 E251 F252 A254 K255 R256 C268 F271 E282 L284 M285 C286 S287 F288
BS02	MN	A	D64 H66 D92	D59 H61 D87
BS03	MN	A	D92 N124 H173 H248	D87 N119 H168 H243

Gene Ontology

Molecular Function

• GO:0016787 hydrolase activity

External links

• PDB: RCSB:8dwk, PDBe:8dwk, PDBj:8dwk
• PDBsum: 8dwk
• PubMed: 37002212
• UniProt: P62136|PP1A_HUMAN Serine/threonine-protein phosphatase PP1-alpha catalytic subunit (Gene Name=PPP1CA)