Structure of PDB 8dw0 Chain A

Receptor sequence
>8dw0A (length=353) Species: 1422 (Geobacillus stearothermophilus) [Search protein sequence]
RFPAREFQRDLLDWFARERRDLPWRKDRDPYKVWVSEVMLQQTRVETVIP
YFEQFIDRFPTLEALADADEDEVLKAWEGLGYYSRVRNLHAAVKEVKTRY
GGKVPDDPDEFSRLKGVGPYTVGAVLSLAYGVPEPAVDGSVMRVLSRLFL
VTDDIAKPSTRKRFEQIVREIMAYENPGAFNEALIELGALVCTPRRPSCL
LCPVQAYCQAFAEGVAEELPVKMKKTAVKQVPLAVAVLADDEGRVLIRKR
DSTGLLANLWEFPSCETDGADGKEKLEQMVGEQGLQVELTEPIVSFEHAF
SHLVWQLTVFPGRLVHGGPVEEPYRLAPEDELKAYAFPVSHQRVWREYKE
WAS
3D structure
PDB8dw0 Structural snapshots of base excision by the cancer-associated variant MutY N146S reveal a retaining mechanism.
ChainA
Resolution1.68 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 3.2.2.31: adenine glycosylase.
Interaction with ligand
Gene Ontology
Molecular Function
GO:0000701 purine-specific mismatch base pair DNA N-glycosylase activity
GO:0003677 DNA binding
GO:0003824 catalytic activity
GO:0016798 hydrolase activity, acting on glycosyl bonds
GO:0019104 DNA N-glycosylase activity
GO:0032357 oxidized purine DNA binding
GO:0034039 8-oxo-7,8-dihydroguanine DNA N-glycosylase activity
GO:0035485 adenine/guanine mispair binding
GO:0046872 metal ion binding
GO:0051539 4 iron, 4 sulfur cluster binding
Biological Process
GO:0006281 DNA repair
GO:0006284 base-excision repair
GO:0006298 mismatch repair
GO:0006950 response to stress

View graph for
Molecular Function
View graph for
Biological Process
External links
PDB RCSB:8dw0, PDBe:8dw0, PDBj:8dw0
PDBsum8dw0
PubMed36631987
UniProtP83847|MUTY_GEOSE Adenine DNA glycosylase (Gene Name=mutY)

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