Structure of PDB 8dvm Chain A

Receptor sequence
>8dvmA (length=612) Species: 9606 (Homo sapiens) [Search protein sequence]
SEAFLLFSRRADIRRISLETNNNNVAIPLTGVKEASALDFDVTDNRIYWT
DISLKTISRAFMNGSALEHVVEFGLDYPEGMAVDWLGKNLYWADTGTNRI
EVSKLDGQHRQVLVWKDLDSPRALALDPAEGFMYWTEWGGKPKIDRAAMD
GSERTTLVPNVGRANGLTIDYAKRRLYWTDLDTNLIESSNMLGLNREVIA
DDLPHPFGLTQYQDYIYWTDWSRRSIERANKTSGQNRTIIQGHLDYVMDI
LVFHSSRQSGWNECASSNGHCSHLCLAVPVGGFVCGCPAHYSLNADNRTC
SAPTTFLLFSQKSAINRMVIDEQQSPDIILPIHSLRNVRAIDYDPLDKQL
YWIDSRQNMIRKAQEDGSQGFTVVVSLEIQPYDLSIDIYSRYIYWTCEAT
NVINVTRLDGRSVGVVLKGEQDRPRAIVVNPEKGYMYFTNLQERSPKIER
AALDGTEREVLFFSGLSKPIALALDSRLGKLFWADSDLRRIESSDLSGAN
RIVLEDSNILQPVGLTVFENWLYWIDKQQQMIEKIDMTGREGRTKVQARI
AQLSDIHAVKELNLQEYRQHPCAQDNGGCSHICLVKGDGTTRCSCPMHLV
LLQDELSCGEPP
3D structure
PDB8dvm Synthetic Multivalent Disulfide-Constrained Peptide Agonists Potentiate Wnt1/ beta-Catenin Signaling via LRP6 Coreceptor Clustering.
ChainA
Resolution2.0 Å
3D
structure
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Enzymatic activity
Enzyme Commision number ?
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 peptide A R639 E663 I681 S682 D705 Y706 E708 T724 W767 R792 W850 Y875 R10 E34 I52 S53 D76 Y77 E79 T95 W138 R163 W221 Y246
BS02 CA A T724 N727 S749 T95 N98 S120
BS03 CA A L1150 I1191 L515 I556
External links
PDB RCSB:8dvm, PDBe:8dvm, PDBj:8dvm
PDBsum8dvm
PubMed36893429
UniProtO75581|LRP6_HUMAN Low-density lipoprotein receptor-related protein 6 (Gene Name=LRP6)

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