Structure of PDB 8dvl Chain A

Receptor sequence
>8dvlA (length=610) Species: 9606 (Homo sapiens) [Search protein sequence]
SEAFLLFSRRADIRRISLETNNNNVAIPLTGVKEASALDFDVTDNRIYWT
DISLKTISRAFMNGSALEHVVEFGLDYPEGMAVDWLGKNLYWADTGTNRI
EVSKLDGQHRQVLVWKDLDSPRALALDPAEGFMYWTEWGGKPKIDRAAMD
GSERTTLVPNVGRANGLTIDYAKRRLYWTDLDTNLIESSNMLGLNREVIA
DDLPHPFGLTQYQDYIYWTDWSRRSIERANKTSGQNRTIIQGHLDYVMDI
LVFHSSRQSGWNECASSNGHCSHLCLAVPVGGFVCGCPAHYSLNADNRTC
SAPTTFLLFSQKSAINRMVIDEQQSPDIILPIHSLRNVRAIDYDPLDKQL
YWIDSRQNMIRKAQEDGSQGFTVVVSEIQPYDLSIDIYSRYIYWTCEATN
VINVTRLDGRSVGVVLKGEQDRPRAIVVNPEKGYMYFTNLQERSPKIERA
ALDGTEREVLFFSGLSKPIALALDSRLGKLFWADSDLRRIESSDLSGANR
IVLEDSNILQPVGLTVFENWLYWIDKQQQMIEKIDMTGREGRTKVQARIA
QLSDIHAVKELNLQEYRQHPCAQDNGGCSHICLVKGDGTTRCSCPMHLVL
LQDELSCGEP
3D structure
PDB8dvl Synthetic Multivalent Disulfide-Constrained Peptide Agonists Potentiate Wnt1/ beta-Catenin Signaling via LRP6 Coreceptor Clustering.
ChainA
Resolution2.5 Å
3D
structure
[Spin on]
[Spin off]
[Reset orientation]

[High quality]
[Low quality]

[White background]
[Black background]

[Download]
[Download structure with residue number starting from 1]
Enzymatic activity
Enzyme Commision number ?
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 peptide A Y706 E708 T724 S749 W767 G768 R792 Y875 Y77 E79 T95 S120 W138 G139 R163 Y246
BS02 CA A L1150 D1190 I1191 L514 D554 I555
External links
PDB RCSB:8dvl, PDBe:8dvl, PDBj:8dvl
PDBsum8dvl
PubMed36893429
UniProtO75581|LRP6_HUMAN Low-density lipoprotein receptor-related protein 6 (Gene Name=LRP6)

[Back to BioLiP]