Structure of PDB 8dsw Chain A

Receptor sequence
>8dswA (length=307) Species: 9606 (Homo sapiens) [Search protein sequence]
TSGEAPNQALLRILKETEFKKIKVLGSGTVYKGLWIPEGEKVKIPVAIKE
LREATSPKANKEILDEAFQEAYVMASVDNPHVCRLLGICLTSTVQLITQL
MPFGCLLDYVREHKDNIGSQYLLNWCVQIAKGMNYLEDRRLVHRDLAARN
VLVKTPQHVKITDFGLAKLLGAEEVPIKWMALESILHRIYTHQSDVWSYG
VTVWELMTFGSKPYDGIPASEISSILEKGERLPQPPICTIDVYMIMVKCW
MIDADSRPKFRELIIEFSKMARDPQRYLVIQGDERMHLRALMDEEDMDDV
VDADEYL
3D structure
PDB8dsw Structural basis for oncogenic activation of the epidermal growth factor receptor by the InsFQEA exon 20 insertion
ChainA
Resolution2.39 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 2.7.10.1: receptor protein-tyrosine kinase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 MG A E762 D859 E66 D163
BS02 ANP A A743 K745 M797 R845 N846 L848 D859 A47 K49 M101 R149 N150 L152 D163
Gene Ontology
Molecular Function
GO:0004672 protein kinase activity
GO:0004713 protein tyrosine kinase activity
GO:0005524 ATP binding
Biological Process
GO:0006468 protein phosphorylation

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Molecular Function
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Biological Process
External links
PDB RCSB:8dsw, PDBe:8dsw, PDBj:8dsw
PDBsum8dsw
PubMed
UniProtP00533|EGFR_HUMAN Epidermal growth factor receptor (Gene Name=EGFR)

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