Structure of PDB 8dsn Chain A

Receptor sequence
>8dsnA (length=308) Species: 10116 (Rattus norvegicus) [Search protein sequence]
NECLGIGPVTPLDASDFALDIRMPGVTPKESDTYFCMSMRLPVDEEAFVI
DFKPRASMDTVHHMLLFGCNMPSSTGSYWFCDEGTCTDKANILYAWARNA
PPTLPKGVGFRVGGETGSKYFVLQVHYGDISAFRDNHKDCSGVSVHLTRV
PQPLIAGMYLMMSVDTVIPPGEKVVNADISCQYKMYPMHVFAYRVHTHHL
GKVVSGYRVRNGQWTLIGRQNPQLPAAFYPVEHPVDVTFGDILAARCVFT
GEGRTEATHIGGTSSDEMCNLYIMYYMEAKYALSFMTCTKNVAPDMFRTI
PAEANIPI
3D structure
PDB8dsn New structures reveal flexible dynamics between the subdomains of peptidylglycine monooxygenase. Implications for an open to closed mechanism.
ChainA
Resolution2.8 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 1.14.17.3: peptidylglycine monooxygenase.
4.3.2.5: peptidylamidoglycolate lyase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 CU A H107 H108 H172 H62 H63 H126
BS02 CU A H242 H244 M314 H196 H198 M268
Gene Ontology
Molecular Function
GO:0003824 catalytic activity
GO:0004497 monooxygenase activity
GO:0005507 copper ion binding
GO:0016715 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced ascorbate as one donor, and incorporation of one atom of oxygen
Biological Process
GO:0006518 peptide metabolic process
Cellular Component
GO:0016020 membrane

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:8dsn, PDBe:8dsn, PDBj:8dsn
PDBsum8dsn
PubMed36880254
UniProtP14925|AMD_RAT Peptidylglycine alpha-amidating monooxygenase (Gene Name=Pam)

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