Structure of PDB 8dsk Chain A

Receptor sequence

>8dskA (length=472) Species: 3847 (Glycine max) [Search protein sequence]

HMDPVSVWGNTPLATVDPEIHDLIEKEKRRQCRGIELIASENFTSFAVIE
ALGSALTNKYSEGMPGNRYYGGNEYIDQIENLCRSRALQAFHLDAQSWGV
NVQPYSGSPANFAAYTAVLNPHDRIMGLDLPSGGHLTHGYYTSGGKKISA
TSIYFESLPYKVNSTTGYIDYDRLEEKALDFRPKLIICGGSAYPRDWDYK
RFREVADKCGALLLCDMAHTSGLVAAQEVNSPFEYCDIVTTTTHKSLRGP
RAGMIFYRKGPKPPKKGQPENAVYDFEDKINFAVFPSLQGGPHNHQIGAL
AVALKQAASPGFKAYAKQVKANAVALGKYLMGKGYSLVTGGTENHLVLWD
LRPLGLTGYKVEKLCDLCNITVNKNAVFGDSSALAPGGVRIGAPAMTSRG
LVEKDFEQIGEFLHRAVTLTLEIQKEHGKLLKDFNKGLVNNKAIEDLKAD
VEKFSALFDMPGFLVSEMKYKD

3D structure

PDB

8dsk Structural and functional analysis of two SHMT8 variants associated with soybean cyst nematode resistance.

Chain

Resolution

1.63 Å

3D
structure

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Enzymatic activity

Enzyme Commision number

2.1.2.1: glycine hydroxymethyltransferase.

Interaction with ligand

Site #	Ligand	Ligand chain	Binding residues on receptor (original residue number in PDB)	Binding residues on receptor (residue number reindexed from 1)
BS01	PLG	A	S39 S105 G106 S107 H134 G189 S190 D215 A217 H218 K244 R389	S40 S106 G107 S108 H135 G190 S191 D216 A218 H219 K245 R390
BS02	FFO	A	L129 G132 G133 H134 L135 Y139 S190 N374 A382	L130 G133 G134 H135 L136 Y140 S191 N375 A383
BS03	PLG	A	Y59 Y69 G289	Y60 Y70 G290
BS04	FFO	A	E61 Y68 Y69 F281	E62 Y69 Y70 F282

Gene Ontology

	Molecular Function
GO:0004372	glycine hydroxymethyltransferase activity
GO:0030170	pyridoxal phosphate binding

	Biological Process
GO:0019264	glycine biosynthetic process from serine
GO:0035999	tetrahydrofolate interconversion

View graph for
Molecular Function

View graph for
Biological Process

External links

PDB	RCSB:8dsk, PDBe:8dsk, PDBj:8dsk
PDBsum	8dsk
PubMed	37811683
UniProt	A0A0R0IK90

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