Structure of PDB 8dpj Chain A

Receptor sequence
>8dpjA (length=180) Species: 11320 (Influenza A virus) [Search protein sequence]
RGSHMEDFVRQCFNPMIVELAEKAMKEYGEDPKIETNKFAAICTHLEVCF
MYSDGGSKHRFEIIEGRDRIMAWTVVNSICNTTGVEKPKFLPDLYDYKEN
RFIEIGVTRREVHIYYLEKANKIKSEKTHIHIFSFTGEEMATKADYTLDE
ESRARIKTRLFTIRQEMASRSLWDSFRQSE
3D structure
PDB8dpj Chemical scaffold recycling: Structure-guided conversion of an HIV integrase inhibitor into a potent influenza virus RNA-dependent RNA polymerase inhibitor designed to minimize resistance potential.
ChainA
Resolution2.45 Å
3D
structure
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Enzymatic activity
Enzyme Commision number ?
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 MN A H41 D108 E119 I120 H45 D93 E104 I105
BS02 MN A E80 P107 D108 E65 P92 D93
BS03 QQ4 A M12 F46 I78 M16 F50 I63
BS04 SE9 A Y24 K34 A37 I38 H41 E119 R124 Y28 K38 A41 I42 H45 E104 R109
Gene Ontology
Biological Process
GO:0039694 viral RNA genome replication

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Molecular Function
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Biological Process
External links
PDB RCSB:8dpj, PDBe:8dpj, PDBj:8dpj
PDBsum8dpj
PubMed36603507
UniProtC6H0Y9

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