Structure of PDB 8dnx Chain A

Receptor sequence
>8dnxA (length=450) Species: 9606 (Homo sapiens) [Search protein sequence]
FLEVIKPFCVILPEIQKPERKIQFKEKVLWTAITLFIFLVCCQIPLFGIM
SSDSADPFYWMRVILASNRGTLMELGISPIVTSGLIMQLLAGAKIIEKDR
ALFNGAQKLFGMIITIGQSIVYVMTGMYGDPSEMGAGICLLITIQLFVAG
LIVLLLDELLQKGYGLGSGISLFIATNICETIVWKAFSPTTVNTGRGMEF
EGAIIALFHLLATRTDKVRALREAFYRQNLPNLMNLIATIFVFAVVIYFQ
GFRYELPIRSTKVRGQIGIYPIKLFYTSNIPIILQSALVSNLYVISQMLS
ARFSGNLLVSLLGTWSAYPVGGLCYYLSPPESFGSVLEDPVHAVVYIVFM
LGSCAFFSKTWIEVSGSSPRDIAKQFKDQGMVINGKRETSIYRELKKIIP
TAAAFGGLCIGALSVLADFLGAIGSGTGILLAVTIIYQYFEIFVKEQSEV
3D structure
PDB8dnx A common mechanism of Sec61 translocon inhibition by small molecules.
ChainA
Resolution2.98 Å
3D
structure
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Enzymatic activity
Enzyme Commision number ?
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 peptide A M65 I68 L69 V85 T86 I123 G126 Q127 V130 I292 A296 N300 M61 I64 L65 V81 T82 I114 G117 Q118 V121 I283 A287 N291
Gene Ontology
Molecular Function
GO:0005048 signal sequence binding
GO:0005262 calcium channel activity
GO:0005515 protein binding
GO:0008320 protein transmembrane transporter activity
GO:0043022 ribosome binding
Biological Process
GO:0006613 cotranslational protein targeting to membrane
GO:0006614 SRP-dependent cotranslational protein targeting to membrane
GO:0006616 SRP-dependent cotranslational protein targeting to membrane, translocation
GO:0006620 post-translational protein targeting to endoplasmic reticulum membrane
GO:0007029 endoplasmic reticulum organization
GO:0015031 protein transport
GO:0031204 post-translational protein targeting to membrane, translocation
GO:0039019 pronephric nephron development
GO:0045047 protein targeting to ER
GO:0045048 protein insertion into ER membrane
GO:0070588 calcium ion transmembrane transport
Cellular Component
GO:0005783 endoplasmic reticulum
GO:0005784 Sec61 translocon complex
GO:0005789 endoplasmic reticulum membrane
GO:0016020 membrane

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:8dnx, PDBe:8dnx, PDBj:8dnx
PDBsum8dnx
PubMed37169959
UniProtP61619|S61A1_HUMAN Protein transport protein Sec61 subunit alpha isoform 1 (Gene Name=SEC61A1)

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