Structure of PDB 8djm Chain A

Receptor sequence
>8djmA (length=237) Species: 10029 (Cricetulus griseus) [Search protein sequence]
DKLSRLFRMHGLFVASHPWEVIVGTVTLTICMMSMNDIIILTITRCIAIL
YIYFQFQNLRQLGSRYILGIAGLFTIFSSFVFSTVVIHFLNEALPFFLLL
IDLSRASALAKFALSSNSQDEVRENIARGMAILGPTFTLDALVECLVIGV
GTMSGVRQLEIMCCFGCMSVLANYFVFMTFFPACVSLVLELSPIWQLSHF
ARVLEEEENRPNPVTQRVKMIMSLGLVLVHAHSRWIA
3D structure
PDB8djm Regulated degradation of HMG CoA reductase requires conformational changes in sterol-sensing domain.
ChainA
Resolution3.23 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 1.1.1.34: hydroxymethylglutaryl-CoA reductase (NADPH).
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 Y01 A L2 P166 T169 L170 L3 P135 T138 L139
BS02 Y01 A L5 F12 L6 F13
BS03 Y01 A C176 T183 R272 C145 T152 R234
BS04 AJP A Q79 D133 S135 R136 E175 I179 E246 Q55 D102 S104 R105 E144 I148 E208
External links
PDB RCSB:8djm, PDBe:8djm, PDBj:8djm
PDBsum8djm
PubMed35879350
UniProtP00347|HMDH_CRIGR 3-hydroxy-3-methylglutaryl-coenzyme A reductase (Gene Name=HMGCR)

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