Structure of PDB 8dg6 Chain A

Receptor sequence
>8dg6A (length=212) Species: 9606 (Homo sapiens) [Search protein sequence]
ILGGREAEAHARPYMASVQNGAHLCGGVLVAEQWVLSAAHCLVQVLLGAH
SLSQPEPSKRLYDVLRAVPHPDSQPDTIDHDLLLLQLSEKATLGPAVRPL
PWQRVDRDVAPGTLCDVAGWGIVNHAGRRPDSLQHVLLPVLDRATCNRTE
RLMCAESNRRDSCKGDSGGPLVCGGVLEGVVTSGSRVCGNRKKPGIYTRV
ASYAAWIDSVLA
3D structure
PDB8dg6 Scaffold hopping via ring opening enables identification of acyclic compounds as new complement Factor D inhibitors.
ChainA
Resolution1.986 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 3.4.21.46: complement factor D.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 S7X A H24 L25 C26 H41 R137 C179 K180 G181 S183 T198 S199 G200 S201 R202 H23 L24 C25 H40 R129 C163 K164 G165 S167 T182 S183 G184 S185 R186
Gene Ontology
Molecular Function
GO:0004252 serine-type endopeptidase activity
GO:0008236 serine-type peptidase activity
Biological Process
GO:0006508 proteolysis
GO:0006956 complement activation
GO:0006957 complement activation, alternative pathway
GO:0009617 response to bacterium
Cellular Component
GO:0005576 extracellular region
GO:0005615 extracellular space
GO:0031093 platelet alpha granule lumen
GO:0034774 secretory granule lumen
GO:0070062 extracellular exosome
GO:1904813 ficolin-1-rich granule lumen

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Biological Process
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Cellular Component
External links
PDB RCSB:8dg6, PDBe:8dg6, PDBj:8dg6
PDBsum8dg6
PubMed36272185
UniProtP00746|CFAD_HUMAN Complement factor D (Gene Name=CFD)

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