Structure of PDB 8dep Chain A

Receptor sequence
>8depA (length=398) Species: 562,9606 [Search protein sequence]
RSWRHLVCYLCFYGFMAQIRPGESFITPYLLGPDKNFTREQVTNEITPVL
SYSYLAVLVPVFLLTDYLRYTPVLLLQGLSFVSVWLLLLLGHSVAHMQLM
ELFYSVTMAARIAYSSYIFSLVRPARYQRVAGYSRAAVLLGVFTSSVLGQ
LLVTVGRVSFSTLNYISLAFLTFSVVLALFLKRPKRSLFLARMLRELGDS
LRRPQLRLWSLWWVFNSAGYYLVVYYVHILWNEVDPTTNSARVYNGAADA
ASTLLGAITSFAAGFVKIRWARWSKLLIAGVTATQAGLVFLLAHTRHPSS
IWLCYAAFVLFRGSYQFLVPIATFQIASSLSKELCALVFGVNTFFATIVK
TIITFIVSDVRGLGLPVRKQFQLYSVYFLILSIIYFLGAMLDGLRHCQ
3D structure
PDB8dep Methotrexate recognition by the human reduced folate carrier SLC19A1.
ChainA
Resolution3.6 Å
3D
structure
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Enzymatic activity
Enzyme Commision number ?
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 AJP A Q172 A312 Q150 A251
Gene Ontology
Molecular Function
GO:0005506 iron ion binding
GO:0008518 folate:monoatomic anion antiporter activity
GO:0009055 electron transfer activity
GO:0015350 methotrexate transmembrane transporter activity
GO:0020037 heme binding
GO:0046872 metal ion binding
GO:0090482 vitamin transmembrane transporter activity
Biological Process
GO:0015884 folic acid transport
GO:0022900 electron transport chain
GO:0051180 vitamin transport
GO:0051958 methotrexate transport
Cellular Component
GO:0005886 plasma membrane
GO:0016020 membrane
GO:0042597 periplasmic space

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Biological Process
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Cellular Component
External links
PDB RCSB:8dep, PDBe:8dep, PDBj:8dep
PDBsum8dep
PubMed36071163
UniProtP0ABE7|C562_ECOLX Soluble cytochrome b562 (Gene Name=cybC);
P41440|S19A1_HUMAN Reduced folate transporter (Gene Name=SLC19A1)

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