Structure of PDB 8deg Chain A

Receptor sequence
>8degA (length=267) Species: 9606 (Homo sapiens) [Search protein sequence]
LWEVPFEEILDLQWVGSGAQGAVFLGRFHGEEVAVKKVRDLKETDIKHLR
KLKHPNIITFKGVCTQAPCYCILMEFCAQGQLYEVLRAGRPVTPSLLVDW
SMGIAGGMNYLHLHKIIHRDLKSPNMLITYDDVVKISDFGGTVAWMAPEV
IRNEPVSEKVDIWSFGVVLWELLTGEIPYKDVDSSAIIWGVGSNSLHLPV
PSSCPDGFKILLRQCWNSKPRNRPSFRQILLHLDIASADVLSTPQETYFK
SQAEWREEVKLHFEKIK
3D structure
PDB8deg Discovery of Potent and Selective Dual Leucine Zipper Kinase/Leucine Zipper-Bearing Kinase Inhibitors with Neuroprotective Properties in In Vitro and In Vivo Models of Amyotrophic Lateral Sclerosis.
ChainA
Resolution2.79 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 2.7.11.25: mitogen-activated protein kinase kinase kinase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 SIQ A V131 G132 S133 Q136 V139 A150 M190 E191 F192 C193 A194 G196 Q197 L243 V15 G16 S17 Q20 V23 A34 M74 E75 F76 C77 A78 G80 Q81 L127
Gene Ontology
Molecular Function
GO:0004672 protein kinase activity
GO:0005524 ATP binding
Biological Process
GO:0006468 protein phosphorylation

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Molecular Function
View graph for
Biological Process
External links
PDB RCSB:8deg, PDBe:8deg, PDBj:8deg
PDBsum8deg
PubMed36469401
UniProtQ12852|M3K12_HUMAN Mitogen-activated protein kinase kinase kinase 12 (Gene Name=MAP3K12)

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