Structure of PDB 8dea Chain A

Receptor sequence
>8deaA (length=217) Species: 9606 (Homo sapiens) [Search protein sequence]
ILGGREAEAHARPYMASVQLNGAHLCGGVLVAEQWVLSAAHCLEGKVQVL
LGAHSLSQPEPSKRLYDVLRAVPHPDSQPDTIDHDLLLLQLSEKATLGPA
VRPLPWQRVDRDVAPGTLCDVAGWGIVNHAGRRPDSLQHVLLPVLDRATC
NTERLMCAESNRRDSCKGDSGGPLVCGGVLEGVVTSGSRVCGNRKKPGIY
TRVASYAAWIDSVLASA
3D structure
PDB8dea Scaffold hopping via ring opening enables identification of acyclic compounds as new complement Factor D inhibitors.
ChainA
Resolution2.214 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 3.4.21.46: complement factor D.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 R7X A L25 R137 C179 K180 G181 S183 S199 S201 R202 L25 R133 C166 K167 G168 S170 S186 S188 R189
Gene Ontology
Molecular Function
GO:0004252 serine-type endopeptidase activity
GO:0008236 serine-type peptidase activity
Biological Process
GO:0006508 proteolysis
GO:0006956 complement activation
GO:0006957 complement activation, alternative pathway
GO:0009617 response to bacterium
Cellular Component
GO:0005576 extracellular region
GO:0005615 extracellular space
GO:0031093 platelet alpha granule lumen
GO:0034774 secretory granule lumen
GO:0070062 extracellular exosome
GO:1904813 ficolin-1-rich granule lumen

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Cellular Component
External links
PDB RCSB:8dea, PDBe:8dea, PDBj:8dea
PDBsum8dea
PubMed36272185
UniProtP00746|CFAD_HUMAN Complement factor D (Gene Name=CFD)

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