Structure of PDB 8ddx Chain A

Receptor sequence

>8ddxA (length=968) Species: 10090 (Mus musculus)

ISKHTQLSPTDAFGTIEFQGGGHSNKAMYVRVSFDTKPDLLLHLMTKEWQ
LELPKLLISVHGGLQNFELQPKLKQVFGKGLIKAAMTTGAWIFTGGVNTG
VIRHVGDALKDHASKSRGKICTIGIAPWGIVENQEDLIGRDVVRPYQTMS
NPMSKLTVLNSMHSHFILADNGTTGKYGAEVKLRRQLEKHISLQKINTRI
GQGVPVVALIVEGGPNVISIVLEYLRDTPPVPVVVCDGSGRASDILAFGH
KYSEVTIQKTFTYTRTQAQHLFIILMECMKKKELITVFRMGSEGHQDIDL
AILTALLKGANASAPDQLSLALAWNRVDIARSQIFIYGQQWPVGSLEQAM
LDALVLDRVDFVKLLIENGVSMHRFLTISRLEELYNTRHGPSNTLYHLVR
DVKKGNLPPDYRISLIDIGLVIEYLMGGAYRCNYTRKRFRTLYHNLNHFP
FPFHELMVWAVLMKRQKMALFFWQHGEEAMAKALVACKLCKAMAHEASEN
DMVDDISQELNHNSRDFGQLAVELLDQSYKQDEQLAMKLLTYELKNWSNA
TCLQLAVAAKHRDFIAHTCSQMLLTDMWMGRLRMRKNSGLKVILGILLPP
SILSLEFKNGRKIYEFYNAPIVKFWFYTLAYIGYLMLFNYIVLVKMERWP
STQEWIVISYIFTLGIEKMREILMSEPGKLLQKVKVWLQEYWNVTDLIAI
LLFSVGMILRLQDQPFRSDGRVIYCVNIIYWYIRLLDIFGVNKYLGPYVM
MIGKMMIDMMYFVIIMLVVLMSFGVARQAILFPNEEPSWKLAKNIFYMPY
WMIYGEVFADQIDPPCQLPPCKTGAWIVPAIMACYLLVANILLVNLLIAV
FNNTFFEVKSISNQVWKFQRYQLIMTFHERPVLPPPLIIFSHMTMIFQHV
CRDYGLKLFITDDELKKVHDFEEQCIEEYFREKDDRFNSSNDERIRVTSE
RVENMSMRLEEVNEREHS

3D structure

• PDB: 8ddx Structural and functional analyses of a GPCR-inhibited ion channel TRPM3.
• Chain: A
• Resolution: 3.8 Å

Interaction with ligand

Site #	Ligand	Ligand chain	Binding residues on receptor (original residue number in PDB)	Binding residues on receptor (residue number reindexed from 1)	Binding affinity
BS01	peptide	A	I129 T133 Q134 S136 P137 T138 F141 V160 D298	I1 T5 Q6 S8 P9 T10 F13 V32 D170
BS02	PIO	A	S773 F990 N993 K994	S588 F739 N742 K743
BS03	9Z9	A	M887 N890 Y891 Y983	M636 N639 Y640 Y732
BS04	9Z9	A	S1039 W1040	S788 W789

Gene Ontology

Molecular Function

• GO:0005216 monoatomic ion channel activity

Biological Process

• GO:0006811 monoatomic ion transport
• GO:0051262 protein tetramerization
• GO:0055085 transmembrane transport

Cellular Component

• GO:0016020 membrane

External links

• PDB: RCSB:8ddx, PDBe:8ddx, PDBj:8ddx
• PDBsum: 8ddx
• PubMed: 36283409
• UniProt: Q5F4S7