Structure of PDB 8dch Chain A

Receptor sequence
>8dchA (length=99) Species: 11676 (Human immunodeficiency virus 1) [Search protein sequence]
PQITLWKRPFVTVKIGGQITEALLDTGADDTIIENISLPGRWKPKIIQGI
GGFLKVRQYDQIPIEIEGHKVIGSVVVGPTPVNVIGRNVMSQLGATLNF
3D structure
PDB8dch HIV-1 protease with 10 lopinavir and darunavir resistance mutations exhibits altered inhibition, structural rearrangements and extreme dynamics.
ChainA
Resolution1.25 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 2.7.7.-
2.7.7.49: RNA-directed DNA polymerase.
2.7.7.7: DNA-directed DNA polymerase.
3.1.-.-
3.1.13.2: exoribonuclease H.
3.1.26.13: retroviral ribonuclease H.
3.4.23.16: HIV-1 retropepsin.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 G52 A D25 G27 D29 D30 I32 Q48 I50 D25 G27 D29 D30 I32 Q48 I50
Gene Ontology
Molecular Function
GO:0004190 aspartic-type endopeptidase activity
Biological Process
GO:0006508 proteolysis

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Molecular Function
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Biological Process
External links
PDB RCSB:8dch, PDBe:8dch, PDBj:8dch
PDBsum8dch
PubMed36108568
UniProtP03367|POL_HV1BR Gag-Pol polyprotein (Gene Name=gag-pol)

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