Structure of PDB 8d95 Chain A

Receptor sequence
>8d95A (length=221) Species: 9606 (Homo sapiens) [Search protein sequence]
ILGGREAEAHARPYMASVQLNGAHLCGGVLVAEQWVLSAAHCLEGKVQVL
LGAHSLSQPEPSKRLYDVLRAVPHPDSQPDTIDHDLLLLQLSEKATLGPA
VRPLPWQRVDRDVAPGTLCDVAGWGIVNHAGRRPDSLQHVLLPVLDRATC
NRRTHTERLMCAESNRRDSCKGDSGGPLVCGGVLEGVVTSGSRVCGNRKK
PGIYTRVASYAAWIDSVLASA
3D structure
PDB8d95 Scaffold hopping via ring opening enables identification of acyclic compounds as new complement Factor D inhibitors.
ChainA
Resolution2.166 Å
3D
structure
[Spin on]
[Spin off]
[Reset orientation]

[High quality]
[Low quality]

[White background]
[Black background]

[Download]
[Download structure with residue number starting from 1]
Enzymatic activity
Enzyme Commision number 3.4.21.46: complement factor D.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 QIE A L25 C26 K180 G181 S183 S199 G200 S201 L25 C26 K171 G172 S174 S190 G191 S192
Gene Ontology
Molecular Function
GO:0004252 serine-type endopeptidase activity
GO:0008236 serine-type peptidase activity
Biological Process
GO:0006508 proteolysis
GO:0006956 complement activation
GO:0006957 complement activation, alternative pathway
GO:0009617 response to bacterium
Cellular Component
GO:0005576 extracellular region
GO:0005615 extracellular space
GO:0031093 platelet alpha granule lumen
GO:0034774 secretory granule lumen
GO:0070062 extracellular exosome
GO:1904813 ficolin-1-rich granule lumen

View graph for
Molecular Function
View graph for
Biological Process
View graph for
Cellular Component
External links
PDB RCSB:8d95, PDBe:8d95, PDBj:8d95
PDBsum8d95
PubMed36272185
UniProtP00746|CFAD_HUMAN Complement factor D (Gene Name=CFD)

[Back to BioLiP]