Structure of PDB 8d8i Chain A

Receptor sequence
>8d8iA (length=201) Species: 9606 (Homo sapiens) [Search protein sequence]
PTVEDVISQVARAHREIFTRTVQEIWEDFSMSFTPAVREVVEFAKHIPGF
RDLSQHDQVTLLKAGTFEVLMVRFASLFNVKDQTVMFLSRTTYSLQELGA
MGMGDLLSAMFDFSEKLNSLALTEEELGLFTAVVLVSADRSGMENSASVE
QLQETLLRALRALVLKNRPLETSRFTKLLLKLPDLRTLNNMHSEKLLSFR
V
3D structure
PDB8d8i Structural basis of synthetic agonist activation of the nuclear receptor REV-ERB.
ChainA
Resolution2.504 Å
3D
structure
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Enzymatic activity
Enzyme Commision number ?
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 peptide A Q433 F443 V447 V451 V469 L472 K473 F477 S603 E604 K605 L606 L607 S608 F609 V611 Q23 F33 V37 V41 V59 L62 K63 F67 S193 E194 K195 L196 L197 S198 F199 V201
BS02 QFX A F439 F443 F477 L480 F484 L487 M496 F497 L498 F29 F33 F67 L70 F74 L77 M86 F87 L88
Gene Ontology
Molecular Function
GO:0003677 DNA binding
GO:0004879 nuclear receptor activity
Biological Process
GO:0006355 regulation of DNA-templated transcription

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Molecular Function
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Biological Process
External links
PDB RCSB:8d8i, PDBe:8d8i, PDBj:8d8i
PDBsum8d8i
PubMed36414641
UniProtP20393|NR1D1_HUMAN Nuclear receptor subfamily 1 group D member 1 (Gene Name=NR1D1)

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