Structure of PDB 8d7p Chain A

Receptor sequence
>8d7pA (length=289) Species: 9606 (Homo sapiens) [Search protein sequence]
ELRVGNRYRLGRKIGSGSFGDIYLGTDIAAGEEVAIKLECVKTKHPQLHI
ESKIYKMMQGGVGIPTIRWCGAEGDYNVMVMELLGPSLEDLFNFCSRKFS
LKTVLLLADQMISRIEYIHSKNFIHRDVKPDNFLMGLGKKGNLVYIIDFG
LAKKYRDARTHQHIPYRENKNLTGTARYASINTHLGIEQSRRDDLESLGY
VLMYFNLGSLPWQGLKAATKRQKYERISEKKMSTPIEVLCKGYPSEFATY
LNFCRSLRFDDKPDYSYLRQLFRNLFHRQGFSYDYVFDW
3D structure
PDB8d7p PERIOD phosphorylation leads to feedback inhibition of CK1 activity to control circadian period.
ChainA
Resolution2.25 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 2.7.11.1: non-specific serine/threonine protein kinase.
2.7.11.26: [tau protein] kinase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 peptide A S19 N172 L173 T174 G175 T176 A177 R178 Q214 G215 K221 Y225 S18 N171 L172 T173 G174 T175 A176 R177 Q213 G214 K220 Y224
Gene Ontology
Molecular Function
GO:0004672 protein kinase activity
GO:0005524 ATP binding
Biological Process
GO:0006468 protein phosphorylation

View graph for
Molecular Function
View graph for
Biological Process
External links
PDB RCSB:8d7p, PDBe:8d7p, PDBj:8d7p
PDBsum8d7p
PubMed37207626
UniProtP48730|KC1D_HUMAN Casein kinase I isoform delta (Gene Name=CSNK1D)

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