Structure of PDB 8d7m Chain A

Receptor sequence
>8d7mA (length=289) Species: 9606 (Homo sapiens) [Search protein sequence]
ELRVGNRYRLGRKIGSGSFGDIYLGTDIAAGEEVAIKLECVKTKHPQLHI
ESKIYKMMQGGVGIPTIRWCGAEGDYNVMVMELLGPSLEDLFNFCSRKFS
LKTVLLLADQMISRIEYIHSKNFIHRDVKPDNFLMGLGKKGNLVYIIDFG
LAKKYRDARTHQHIPYRENKNLTGTARYASINTHLGIEQSRRDDLESLGY
VLMYFNLGSLPWQGLKAATKRQKYERISEKKMSTPIEVLCKGYPSEFATY
LNFCRSLRFDDKPDYSYLRQLFRNLFHRQGFSYDYVFDW
3D structure
PDB8d7m PERIOD phosphorylation leads to feedback inhibition of CK1 activity to control circadian period.
ChainA
Resolution2.25 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 2.7.11.1: non-specific serine/threonine protein kinase.
2.7.11.26: [tau protein] kinase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 peptide A G18 S19 D128 K130 L152 L173 T174 G175 R178 Q214 G215 K224 Y225 G17 S18 D127 K129 L151 L172 T173 G174 R177 Q213 G214 K223 Y224
Gene Ontology
Molecular Function
GO:0004672 protein kinase activity
GO:0005524 ATP binding
Biological Process
GO:0006468 protein phosphorylation

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Molecular Function
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Biological Process
External links
PDB RCSB:8d7m, PDBe:8d7m, PDBj:8d7m
PDBsum8d7m
PubMed37207626
UniProtP48730|KC1D_HUMAN Casein kinase I isoform delta (Gene Name=CSNK1D)

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