Structure of PDB 8d6f Chain A

Receptor sequence
>8d6fA (length=270) Species: 9606 (Homo sapiens) [Search protein sequence]
QPRRVSFRSPGYDPSRPESFFQQSFQRLSRLGHGSYGEVFKVRSKEDGRL
YAVKRSMSPFRGPKDRARKLAEVGSHEKVGQHPCCVRLEQAWEEGGILYL
QTELCGPSLQQHCEAWGASLPEAQVWGYLRDTLLALAHLHSQGLVHLDVK
PANIFLGPRGRCKLGDFGLLVELGVQEGDPRYMAPELLQGSYGTAADVFS
LGLTILEVACNMELPHGGEGWQQLRQGYLPPEFTAGLSSELRSVLVMMLE
PDPKLRATAEALLALPVLRQ
3D structure
PDB8d6f Discovery of an Orally Bioavailable and Selective PKMYT1 Inhibitor, RP-6306.
ChainA
Resolution2.49 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 2.7.11.1: non-specific serine/threonine protein kinase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 QG5 A Y121 V124 H161 T187 L189 C190 F240 D251 Y36 V39 H76 T102 L104 C105 F155 D166
Gene Ontology
Molecular Function
GO:0004672 protein kinase activity
GO:0005524 ATP binding
Biological Process
GO:0006468 protein phosphorylation

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Molecular Function
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Biological Process
External links
PDB RCSB:8d6f, PDBe:8d6f, PDBj:8d6f
PDBsum8d6f
PubMed35880755
UniProtQ99640|PMYT1_HUMAN Membrane-associated tyrosine- and threonine-specific cdc2-inhibitory kinase (Gene Name=PKMYT1)

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