Structure of PDB 8d6d Chain A

Receptor sequence
>8d6dA (length=270) Species: 9606 (Homo sapiens) [Search protein sequence]
QPRRVSFRPGYDPSRPESFFQQSFQRLSRLGHGSYGEVFKVRSKEDGRLY
AVKRSMSPFRGPKDRARKLAEVGSHEKVGQHPCCVRLEQAWEEGGILYLQ
TELCGPSLQQHCEAWGASLPEAQVWGYLRDTLLALAHLHSQGLVHLDVKP
ANIFLGPRGRCKLGDFGLLVELGEVQEGDPRYMAPELLQGSYGTAADVFS
LGLTILEVACNMELPHGGEGWQQLRQGYLPPEFTAGLSSELRSVLVMMLE
PDPKLRATAEALLALPVLRQ
3D structure
PDB8d6d Discovery of an Orally Bioavailable and Selective PKMYT1 Inhibitor, RP-6306.
ChainA
Resolution2.35 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 2.7.11.1: non-specific serine/threonine protein kinase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 QGY A L116 Y121 V124 K139 T187 L189 C190 F240 D251 L30 Y35 V38 K53 T101 L103 C104 F154 D165
Gene Ontology
Molecular Function
GO:0004672 protein kinase activity
GO:0005524 ATP binding
Biological Process
GO:0006468 protein phosphorylation

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Molecular Function
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Biological Process
External links
PDB RCSB:8d6d, PDBe:8d6d, PDBj:8d6d
PDBsum8d6d
PubMed35880755
UniProtQ99640|PMYT1_HUMAN Membrane-associated tyrosine- and threonine-specific cdc2-inhibitory kinase (Gene Name=PKMYT1)

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