Structure of PDB 8d4a Chain A

Receptor sequence
>8d4aA (length=1207) Species: 1539066 (Sulfuricurvum sp. PC08-66) [Search protein sequence]
MLHAFTNQYQLSKTLRFGATLKEDEKKCKSHEELKGFVDISYENMKSSAT
ENELVKKCERCYSEIVKFHNAWEKIYYRTDQIAVYKDFYRQLSRKARFDA
GKQNSQLITLASLCGMYQGAKLSRYITNYWKDNITRQKSFLKDFSQQLHQ
YTRALEKSDKAHTKPNLINFNKTFMVLANLVNEIVIPLSNGAISFPNISK
LEDGEESHLIEFALNDYSQLSELIGELKDAIATNGGYTPFAKVTLNHYTA
EQKPHVFKNDIDAKIRELKLIGLVETLKGKSSEQIEEYFSNLDKFSTYND
RNQSVIVRTQCFKYKPIPFLVKHQLAKYISEPNGWDEDAVAKVLDAVGAI
RSPAHDYANNQEGFDLNHYPIKVAFDYAWEQLANSLYTTVTFPQEMCEKY
LNSIYGCEVSKEPVFKFYADLLYIRKNLAVLEHKNNLPSNQEEFICKINN
TFENIVLPYKISQFETYKKDILAWINDGHDHKKYTDAKQQLGFIRGGLKG
RINPYTKLTNEFKQISSTYGKTFAELRDKFKEKNEITKITHFGIIIEDKN
RDRYLLASELKHEQINHVSTILNKLDKSSEFITYQVKSLTSKTLIKLIKN
HTTKKGAISPYADFHTSKTGFNKNEIEKNWDNYKREQVLVEYVKDCLTDS
TMAKNQNWAEFGWNFEKCNSYEDIEHEIDQKSYLLQSDTISKQSIASLVE
GGCLLLPIINQDITSKERKDKNQFSKDWNHIFEGSKEFRLHPEFAVSYRT
PIEGYPVQKRYGRLQFVCAFNAHIVPQNGEFINLKKQIENFNDEDVQKRN
VTEFNKKVNHALSDKEYVVIGIDRGLKQLATLCVLDKRGKILGDFEIYKK
EFVRAEKRSESHWEHTQAETRHILDLSNLRVETTIEGKKVLVDQSLTLVK
KNRDTPDEEATEENKQKIKLKQLSYIRKLQHKMQTNEQDVLDLINNEPSD
EEFKKRIEGLISSFGEGQKYADLPINTMREMISDLQGVIARGNNQTEKNK
IIELDAADNLKQGIVANMIGIVNYIFAKYSYKAYISLEDLSRAYGGAKSG
YDGRYLPSTSQDEDVDFKEQQNQMLAGLGTYQFFEMQLLKKLQKIQSDNT
VLRFVPAFRSADNYRNILRLEETKYKSKPFGVVHFIDPKFTSKKCPVCSK
TNVYRDKDDILVCKECGFRSDSQLKERENNIHYIHNGDDNGAYHIALKSV
ENLIQMK
3D structure
PDB8d4a RNA targeting unleashes indiscriminate nuclease activity of CRISPR-Cas12a2.
ChainA
Resolution2.74 Å
3D
structure
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Enzymatic activity
Enzyme Commision number ?
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 rna A S12 K13 T14 R16 F17 G18 K22 E25 K26 K27 C28 S164 D165 A167 H168 K178 N240 K321 H361 T394 T397 N442 S445 K538 S541 G545 R552 N735 Q736 S740 K741 K746 N747 F749 R774 Q783 K784 R785 Y786 R788 F877 R883 S884 S886 W888 R905 V906 E907 T908 V924 K925 R928 D929 P931 N939 K944 H956 Q959 T960 N1034 L1035 G1038 A1041 R1079 K1116 K1119 S12 K13 T14 R16 F17 G18 K22 E25 K26 K27 C28 S158 D159 A161 H162 K172 N234 K315 H355 T388 T391 N436 S439 K513 S516 G520 R527 N710 Q711 S715 K716 K721 N722 F724 R749 Q758 K759 R760 Y761 R763 F852 R858 S859 S861 W863 R880 V881 E882 T883 V899 K900 R903 D904 P906 N914 K919 H931 Q934 T935 N1009 L1010 G1013 A1016 R1054 K1091 K1094
BS02 rna A R103 Y123 H168 K170 L173 Y254 K259 H261 V262 D382 E386 R431 A435 H439 K546 E550 K554 S613 T615 K617 T618 K621 N625 T627 Y636 K648 Q681 H766 P767 E768 I813 R952 E1028 L1029 A1031 A1032 K1036 E1094 N1097 Q1107 R1134 S1135 A1136 D1137 R97 Y117 H162 K164 L167 Y248 K253 H255 V256 D376 E380 R425 A429 H433 K521 E525 K529 S588 T590 K592 T593 K596 N600 T602 Y611 K623 Q656 H741 P742 E743 I788 R927 E1003 L1004 A1006 A1007 K1011 E1069 N1072 Q1082 R1109 S1110 A1111 D1112
BS03 dna A L851 K852 G992 Q993 K994 L1065 R1067 A1068 Y1069 F1092 Q1096 P1163 F1165 S1167 L826 K827 G967 Q968 K969 L1040 R1042 A1043 Y1044 F1067 Q1071 P1138 F1140 S1142
BS04 dna A Y465 R1067 Y1069 Y1080 S1083 S1085 R1144 K1151 D1162 K1164 F1165 K1169 T1176 K1223 Y459 R1042 Y1044 Y1055 S1058 S1060 R1119 K1126 D1137 K1139 F1140 K1144 T1151 K1198
BS05 ZN A C1170 C1188 C1191 C1145 C1163 C1166
BS06 MG A D848 E1063 D823 E1038
BS07 MG A D848 D1213 D823 D1188
Gene Ontology

View graph for
Molecular Function
External links
PDB RCSB:8d4a, PDBe:8d4a, PDBj:8d4a
PDBsum8d4a
PubMed36599980
UniProtA0A0C2W1L1

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