Structure of PDB 8d40 Chain A

Receptor sequence

>8d40A (length=422) Species: 9606 (Homo sapiens)

GRGSLKFPMPNYQVALFENEPAGTLILQLHAHYTIEGEEERVSYYMEGLF
DERSRGYFRIDSATGAVSTDSVLDRETKETHVLRVKAVDYSTPPRSATTY
ITVLVKDTNDHSPVFEQSEYRERVRENLEVGYEVLTIRASDRDSPINANL
RYRVLGGAWDVFQLNESSGVVSTRAVLDREEAAEYQLLVEANDQGRNPGP
LSATATVYIEVEDENDNYPQFSEQNYVVQVPEDVGLNTAVLRVQATDRDQ
GQNAAIHYSILSGNVAGQFYLHSLSGILDVINPLDFEDVQKYSLSIKAQD
GGRPPLINSSGVVSVQVLDVNDNEPIFVSSPFQATVLENVPLGYPVVHIQ
AVDADSGENARLHYRLVDDFPFQIHNSSGWITVCAELDREEVEHYSFGVE
AVDHGSPPMSSSTSVSITVLDV

3D structure

• PDB: 8d40 Crystal structure of human CELSR1 EC1-4
• Chain: A
• Resolution: 3.554 Å

Interaction with ligand

Site #	Ligand	Ligand chain	Binding residues on receptor (original residue number in PDB)	Binding residues on receptor (residue number reindexed from 1)	Binding affinity
BS01	CA	A	E21 E79 D110 D113 D146	E18 E76 D107 D110 D143
BS02	CA	A	N112 H114 D144 D146 N150 D196	N109 H111 D141 D143 N147 D193
BS03	CA	A	E129 N130 D181 E183 D219	E126 N127 D178 E180 D216
BS04	CA	A	E129 E183 D216 E217 D219 D252	E126 E180 D213 E214 D216 D249
BS05	CA	A	N218 N220 D250 D252 N256 D303	N215 N217 D247 D249 N253 D300
BS06	CA	A	D288 E290 D325	D285 E287 D322
BS07	CA	A	E235 E290 D322 V323 D325 D358	E232 E287 D319 V320 D322 D355
BS08	CA	A	N324 N326 D356 D358 N362 D426	N321 N323 D353 D355 N359 D403

Gene Ontology

Molecular Function

• GO:0005509 calcium ion binding

Biological Process

• GO:0007155 cell adhesion
• GO:0007156 homophilic cell adhesion via plasma membrane adhesion molecules

Cellular Component

• GO:0005886 plasma membrane
• GO:0016020 membrane

External links

• PDB: RCSB:8d40, PDBe:8d40, PDBj:8d40
• PDBsum: 8d40
• UniProt: Q9NYQ6|CELR1_HUMAN Cadherin EGF LAG seven-pass G-type receptor 1 (Gene Name=CELSR1)