Structure of PDB 8d3o Chain A

Receptor sequence
>8d3oA (length=436) Species: 9606 (Homo sapiens) [Search protein sequence]
KAPSHVPFLLIGGGTAAFAAARSIRARDPGARVLIVSEDPELPYMRPPLS
KELWFSPNVTKTLRFKQWNGKERSIYFQPPSFYVSAQDLPHIENGGVAVL
TGKKVVQLDVRDNMVKLNDGSQITYEKCLIATGGTPRSLSAIDRAGAEVK
SRTTLFRKIGDFRSLEKISREVKSITIIGGGFLGSELACALGRKARALGT
EVIQLFPEKGNMGKILPEYLSNWTMEKVRREGVKVMPNAIVQSVGVSSGK
LLIKLKDGRKVETDHIVAAVGLEPNVELAKTGGLEIDSDFGGFRVNAELQ
ARSNIWVAGDAACFYDIKLGRRRVEHHDHAVVSGRLAGENMTGAAKPYWH
QSMFWSDLGPDVGYEAIGLVDSSLPTVGVFAGKGVIFYLRDKVVVGIVLW
NIFNRMPIARKIIKDGEQHEDLNEVAKLFNIHVLFQ
3D structure
PDB8d3o Integrating early structural selection into chemical library screening for drug discovery with high-throughput small-angle X-ray scattering (SAXS)
ChainA
Resolution2.25 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 1.6.99.-
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 QF6 A F310 L311 E314 E453 H454 F482 F182 L183 E186 E325 H326 F354
BS02 FAD A G138 A142 E164 D165 R172 P173 K177 K232 V233 T260 G261 F284 R285 G437 D438 E453 H454 H455 A458 G12 A16 E38 D39 R46 P47 K51 K104 V105 T132 G133 F156 R157 G309 D310 E325 H326 H327 A330
Gene Ontology
Molecular Function
GO:0016491 oxidoreductase activity
GO:0046983 protein dimerization activity

View graph for
Molecular Function
External links
PDB RCSB:8d3o, PDBe:8d3o, PDBj:8d3o
PDBsum8d3o
PubMed38671223
UniProtO95831|AIFM1_HUMAN Apoptosis-inducing factor 1, mitochondrial (Gene Name=AIFM1)

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