Structure of PDB 8d3n Chain A

Receptor sequence

>8d3nA (length=437) Species: 9606 (Homo sapiens) [Search protein sequence]

KAPSHVPFLLIGGGTAAFAAARSIRARDPGARVLIVSEDPELPYMRPPLS
KELWFSDDPNVTKTLRFKQNGKERSIYFQPPSFYVSAQDLPHIENGGVAV
LTGKKVVQLDVRDNMVKLNDGSQITYEKCLIATGGTPRSLSAIDRAGAEV
KSRTTLFRKIGDFRSLEKISREVKSITIIGGGFLGSELACALGRKARALG
TEVIQLFPEKGNMGKILPEYLSNWTMEKVRREGVKVMPNAIVQSVGVSSG
KLLIKLKDGRKVETDHIVAAVGLEPNVELAKTGGLEIDSDFGGFRVNAEL
QARSNIWVAGDAACFYDIKLGRRRVEHHDHAVVSGRLAGENMTGAAKPYW
HQSMFWSDLGPDVGYEAIGLVDSSLPTVGVFAGKGVIFYLRDKVVVGIVL
WNIFNRMPIARKIIKDGEQHEDLNEVAKLFNIHVLFQ

3D structure

PDB

8d3n Integrating early structural selection into chemical library screening for drug discovery with high-throughput small-angle X-ray scattering (SAXS)

Chain

Resolution

2.25 Å

3D
structure

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Enzymatic activity

Enzyme Commision number

1.6.99.-

Interaction with ligand

Site #	Ligand	Ligand chain	Binding residues on receptor (original residue number in PDB)	Binding residues on receptor (residue number reindexed from 1)	Binding affinity
BS01	QBC	A	F310 L311 E314 F482 W483 S484	F183 L184 E187 F355 W356 S357
BS02	FAD	A	G138 G139 A142 E164 D165 R172 P173 K177 K232 V233 T260 G261 F284 R285 G437 D438 E453 H454 H455 A458 W483	G12 G13 A16 E38 D39 R46 P47 K51 K105 V106 T133 G134 F157 R158 G310 D311 E326 H327 H328 A331 W356

Gene Ontology

	Molecular Function
GO:0016491	oxidoreductase activity
GO:0046983	protein dimerization activity

View graph for
Molecular Function

External links

PDB	RCSB:8d3n, PDBe:8d3n, PDBj:8d3n
PDBsum	8d3n
PubMed	38671223
UniProt	O95831\|AIFM1_HUMAN Apoptosis-inducing factor 1, mitochondrial (Gene Name=AIFM1)

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