Structure of PDB 8d3j Chain A

Receptor sequence
>8d3jA (length=436) Species: 9606 (Homo sapiens) [Search protein sequence]
KAPSHVPFLLIGGGTAAFAAARSIRARDPGARVLIVSEDPELPYMRPPLS
KELWFSDDPNVTKTLRFKQKERSIYFQPPSFYVSAQDLPHIENGGVAVLT
GKKVVQLDVRDNMVKLNDGSQITYEKCLIATGGTPRSLSAIDRAGAEVKS
RTTLFRKIGDFRSLEKISREVKSITIIGGGFLGSELACALGRKARALGTE
VIQLFPEKGNMGKILPEYLSNWTMEKVRREGVKVMPNAIVQSVGVSSGKL
LIKLKDGRKVETDHIVAAVGLEPNVELAKTGGLEIDSDFGGFRVNAELQA
RSNIWVAGDAACFYDIKLGRRRVEHHDHAVVSGRLAGENMTGAAKPYWHQ
SMFWSDLGPDVGYEAIGLVDSSLPTVGVFAYGKGVIFYLRDKVVVGIVLW
NIFNRMPIARKIIKDGEQHEDLNEVAKLFNIHVLFQ
3D structure
PDB8d3j Integrating early structural selection into chemical library screening for drug discovery with high-throughput small-angle X-ray scattering (SAXS)
ChainA
Resolution2.4 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 1.6.99.-
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 FAD A G138 A142 E164 D165 R172 P173 K177 K232 V233 T260 F284 R285 G437 D438 E453 H454 H455 W483 G12 A16 E38 D39 R46 P47 K51 K103 V104 T131 F155 R156 G308 D309 E324 H325 H326 W354
BS02 QEF A F310 L311 E314 H454 F482 W483 S484 F181 L182 E185 H325 F353 W354 S355
Gene Ontology
Molecular Function
GO:0016491 oxidoreductase activity
GO:0046983 protein dimerization activity

View graph for
Molecular Function
External links
PDB RCSB:8d3j, PDBe:8d3j, PDBj:8d3j
PDBsum8d3j
PubMed38671223
UniProtO95831|AIFM1_HUMAN Apoptosis-inducing factor 1, mitochondrial (Gene Name=AIFM1)

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