Structure of PDB 8d3i Chain A

Receptor sequence
>8d3iA (length=439) Species: 9606 (Homo sapiens) [Search protein sequence]
KAPSHVPFLLIGGGTAAFAAARSIRARDPGARVLIVSEDPELPYMRPPLS
KELWFSDDPNVTKTLRFKQANGKERSIYFQPPSFYVSAQDLPHIENGGVA
VLTGKKVVQLDVRDNMVKLNDGSQITYEKCLIATGGTPRSLSAIDRAGAE
VKSRTTLFRKIGDFRSLEKISREVKSITIIGGGFLGSELACALGRKARAL
GTEVIQLFPEKGNMGKILPEYLSNWTMEKVRREGVKVMPNAIVQSVGVSS
GKLLIKLKDGRKVETDHIVAAVGLEPNVELAKTGGLEIDSDFGGFRVNAE
LQARSNIWVAGDAACFYDIKLGRRRVEHHDHAVVSGRLAGENMTGAAKPY
WHQSMFWSDLGPDVGYEAIGLVDSSLPTVGVFAYGKGVIFYLRDKVVVGI
VLWNIFNRMPIARKIIKDGEQHEDLNEVAKLFNIHVLFQ
3D structure
PDB8d3i Integrating early structural selection into chemical library screening for drug discovery with high-throughput small-angle X-ray scattering (SAXS)
ChainA
Resolution2.65 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 1.6.99.-
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 1LM A F310 L311 E314 W483 F184 L185 E188 W357
BS02 FAD A G138 A142 E164 D165 R172 P173 K177 K232 V233 T260 F284 G437 D438 E453 H454 H455 W483 G12 A16 E38 D39 R46 P47 K51 K106 V107 T134 F158 G311 D312 E327 H328 H329 W357
Gene Ontology
Molecular Function
GO:0016491 oxidoreductase activity
GO:0046983 protein dimerization activity

View graph for
Molecular Function
External links
PDB RCSB:8d3i, PDBe:8d3i, PDBj:8d3i
PDBsum8d3i
PubMed38671223
UniProtO95831|AIFM1_HUMAN Apoptosis-inducing factor 1, mitochondrial (Gene Name=AIFM1)

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