Structure of PDB 8d3e Chain A

Receptor sequence
>8d3eA (length=433) Species: 9606 (Homo sapiens) [Search protein sequence]
APSHVPFLLIGGGTAAFAAARSIRARDPGARVLIVSEDPELPYMRPPLSK
ELWFSDDPNVTKTLRFKQANGKERSIYFQPPSFYVSAQDLPHIENGGVAV
LTGKKVVQLDVRDNMVKLNDGSQITYEKCLIATGGTPRSLSAIDRAGAEV
KSRTTLFRKIGDFRSLEKISREVKSITIIGGGFLGSELACALGRKARALG
TEVIQLFPEKGNMGKILPEYLSNWTMEKVRREGVKVMPNAIVQSVGVSSG
KLLIKLKDGRKVETDHIVAAVGLEPNVELAKTGGLEIDSDFGGFRVNAEL
QARSNIWVAGDAACFYDIKLGRRRVEHHDHAVVSGRLAGENMTGAAKPYW
HQSMFWSDLGPDVGYEAIGLVDSSLPTVGVFAGKGVIFYLRDKVVVGIVL
WNIFNRMPIARKIIKDGEQHEDLNEVAKLFNIH
3D structure
PDB8d3e Integrating early structural selection into chemical library screening for drug discovery with high-throughput small-angle X-ray scattering (SAXS)
ChainA
Resolution2.38 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 1.6.99.-
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 FAD A G138 G139 A142 E164 D165 R172 P173 K177 K232 V233 T260 F284 R285 G437 D438 E453 H454 H455 A458 W483 G11 G12 A15 E37 D38 R45 P46 K50 K105 V106 T133 F157 R158 G310 D311 E326 H327 H328 A331 W356
BS02 QDI A F310 L311 E314 E453 H454 F482 F183 L184 E187 E326 H327 F355
Gene Ontology
Molecular Function
GO:0016491 oxidoreductase activity
GO:0046983 protein dimerization activity

View graph for
Molecular Function
External links
PDB RCSB:8d3e, PDBe:8d3e, PDBj:8d3e
PDBsum8d3e
PubMed38671223
UniProtO95831|AIFM1_HUMAN Apoptosis-inducing factor 1, mitochondrial (Gene Name=AIFM1)

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