Structure of PDB 8d2s Chain A

Receptor sequence

>8d2sA (length=475) Species: 7955 (Danio rerio) [Search protein sequence]

SRLSVCSKLCYAIGGAPYQITGCAIGFFLQIYLLDVALLDPFYASIILFV
GRAWDAVTDPTVGFLVSRTPWTRFGRMMPWIVLSTPFAVLCYFLIWYVPS
VDQGKVVWYLIFYCCFQTLQTCFHVPYSALTMFISTEQKERDSATAYRMT
VEVLGTLIGTAIQGQIVGMANAPCISTEIDLQSTGLEVAPDVQITDPHVS
LQDLRNAYMIASGVICAIYVVCAVVLFLGVKEQKDTCRVRTEPMSFFQGI
CMVMGHGPYAKLVMGFLFTSLAFMLLEGNFALFCIYNLGFRNDFQNVLLV
IMLSATLAIPFWQWFLTKFGKKTAVYIGTTSVVPFLISVVLVPSSLAVTY
IASFAAGVSVAAAFLLPWSMLPDVVDDFKVQNPESQGHEAIFYSFYVFFT
KFASGVSLGVSTLSLDFAGYVTRGCTQPGEVKLTLKILVSAAPIVLIIIG
LLIFISYPINEEKRQGNRKLLNEQR

3D structure

PDB

8d2s Lipid flipping in the omega-3 fatty-acid transporter.

Chain

Resolution

2.9 Å

3D
structure

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Enzymatic activity

Enzyme Commision number

Interaction with ligand

Site #	Ligand	Ligand chain	Binding residues on receptor (original residue number in PDB)	Binding residues on receptor (residue number reindexed from 1)
BS01	ZGS	A	R84 D87 F312 A388 F396 Y425 T432 K433	R52 D55 F280 A356 F364 Y393 T400 K401
BS02	ZGS	A	R180 M181 E184 V185 T188 L189 M334 A337 T338 I341 W400 E421 Y425	R148 M149 E152 V153 T156 L157 M302 A305 T306 I309 W368 E389 Y393
BS03	ZGS	A	D174 T182 T338 L339 W400 E421	D142 T150 T306 L307 W368 E389

Gene Ontology

	Molecular Function
GO:0015245	fatty acid transmembrane transporter activity
GO:0015293	symporter activity
GO:0051978	lysophospholipid:sodium symporter activity

	Biological Process
GO:0006869	lipid transport
GO:0008643	carbohydrate transport
GO:0015908	fatty acid transport
GO:0045056	transcytosis
GO:0051977	lysophospholipid transport
GO:0055085	transmembrane transport
GO:0060856	establishment of blood-brain barrier
GO:0140329	lysophospholipid translocation
GO:1990379	lipid transport across blood-brain barrier

	Cellular Component
GO:0005783	endoplasmic reticulum
GO:0005789	endoplasmic reticulum membrane
GO:0005886	plasma membrane
GO:0016020	membrane

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Molecular Function

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Biological Process

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Cellular Component

External links

PDB	RCSB:8d2s, PDBe:8d2s, PDBj:8d2s
PDBsum	8d2s
PubMed	37156797
UniProt	Q6DEJ6\|NLS1B_DANRE Sodium-dependent lysophosphatidylcholine symporter 1-B (Gene Name=mfsd2ab)

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