Structure of PDB 8d2k Chain A

Receptor sequence
>8d2kA (length=1105) Species: 351607 (Acidothermus cellulolyticus 11B) [Search protein sequence]
GTVPVTWRLGVDVGERSIGLAAVSYEEDKPKEILAAVSWIHDGGVGDERS
GASRLALRGMARRARRLRRFRRARLRDLDMLLSELGWTPLPDKNVSPVDA
WLARKRLAEEYVVDETERRRLLGYAVSHMARHRGWRNPWTTIKDLKNLPQ
PSDSWERTRESLEARYSVSLEPGTVGQWAGYLLQRAPGIRLNPTQQSLSN
ATAFETRLRQEDVLWELRCIADVQGLPEDVVSNVIDAVFCQKRPSVPAER
IGRDPLDPSQLRASRACLEFQEYRIVAAVANLRIRDGSGSRPLSLEERNA
VIEALLAQTERSLTWSDIALEILKLPNESDLTSVPEEDGPSSLAYSQFAP
FDETSARIAEFIAKNRRKIPTFAQWWQEQDRTSRSDLVAALADNSIAGLL
VHLPDAELEALEGLALPSGRVAYSRLTLSGLTRVMRDDGVDVHNARKTCF
GVDDNWRPPLPALHEATGHPVVDRNLAILRKFLSSATMRWGPPQSIVVEL
ARGASESRERQAEEEAARRAHRKANDRIRAELRASGLSDPSPADLVRARL
LELYDCHCMYCGAPISWENSELDHIVPRTDGGSNRHENLAITCGACNKEK
GRRPFASWAETSNRVQLRDVIDRVQKLKYSGNMYWTRDEFSRYKKSVVAR
LKRRTSDPEVIQSIESTGYAAVALRDRLLSYGEKNGVAQVAVFRGGVTAE
ARRWLDISIERLFSRVAIFAQSTSTKRLDRRHHAVDAVVLTTLTPGVAKT
LADARSRRVSASTEEPQSPAYRQWKESCSGLGDLLISTAARDSIAVAAPL
RLRPTGALHEETLRAFSEHTVGAAWKGAELRRIVEPEVYAAFLALTDPGG
RFLKVSPSEDVLPADENRHIVLSDRVLGPRDRVKLFPDDRGSIRVRGGAA
YIASFHHARVFRWGSSHSPSFALLRVSLADLAVAGLLRDGVDVFTAELPP
WTPAWRYASIALVKAVESGDAKQVGWLVPGDELDFGPEGVTTAAGDLSMF
LKYFPERHWVVTGFEDDKRINLKPAFLSAEQAEVLRTERSDRPDTLTEAG
EILAQFFPRCWRATVAKVLCHPGLTVIRRTALGQPRWRRGHLPYSWRPWS
ADPWS
3D structure
PDB8d2k Coupled catalytic states and the role of metal coordination in Cas9
ChainA
Resolution2.43 Å
3D
structure
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Enzymatic activity
Enzyme Commision number ?
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 rna A H47 D48 S59 R60 L61 A62 R64 R68 R69 R71 R72 L73 R74 R75 F76 R78 R82 L96 D98 K99 N100 V101 S102 P103 W107 H134 R137 H138 R139 G140 W141 P144 P193 G194 I195 R196 L197 N198 T200 Q201 Q253 K254 P256 S257 R262 R277 F282 Y285 R286 A439 Y440 R463 R474 H486 P487 R491 R497 K498 S501 S502 M505 R506 R519 H538 R539 N542 R546 S600 N601 R602 H603 K615 Y651 E682 R692 V709 R711 K766 L829 R830 L831 R832 T834 G835 A836 L837 H838 L842 R843 A844 R925 G969 V970 D971 V972 F973 T1109 L1111 Q1113 R1115 W1116 R1117 H1120 L1121 P1122 H41 D42 S53 R54 L55 A56 R58 R62 R63 R65 R66 L67 R68 R69 F70 R72 R76 L90 D92 K93 N94 V95 S96 P97 W101 H128 R131 H132 R133 G134 W135 P138 P187 G188 I189 R190 L191 N192 T194 Q195 Q241 K242 P244 S245 R250 R265 F270 Y273 R274 A422 Y423 R446 R457 H469 P470 R474 R480 K481 S484 S485 M488 R489 R502 H521 R522 N525 R529 S583 N584 R585 H586 K598 Y634 E665 R675 V692 R694 K749 L800 R801 L802 R803 T805 G806 A807 L808 H809 L813 R814 A815 R896 G940 V941 D942 V943 F944 T1080 L1082 Q1084 R1086 W1087 R1088 H1091 L1092 P1093
BS02 dna A R55 T596 N614 G618 R619 E839 E840 T841 R843 G1024 D1025 R1048 R1088 R1091 T1093 K1096 R49 T579 N597 G601 R602 E810 E811 T812 R814 G995 D996 R1019 R1059 R1062 T1064 K1067
BS03 dna A W141 N143 W145 R219 V258 R262 I263 G264 R274 N293 R295 S345 V346 E349 S435 G436 R437 D458 H460 D471 N472 R474 R519 R535 R564 E588 L589 D590 H591 R595 N614 E682 Y686 V689 G763 A799 W135 N137 W139 R207 V246 R250 I251 G252 R262 N281 R283 S333 V334 E337 S418 G419 R420 D441 H443 D454 N455 R457 R502 R518 R547 E571 L572 D573 H574 R578 N597 E665 Y669 V672 G746 A770
BS04 dna A D18 G20 E21 R22 S23 E54 R55 P675 I678 Q679 K743 R744 R747 H750 R919 F934 R954 T1041 G1042 F1043 E1044 E1059 D12 G14 E15 R16 S17 E48 R49 P658 I661 Q662 K726 R727 R730 H733 R890 F905 R925 T1012 G1013 F1014 E1015 E1030
BS05 MG A D590 N614 D573 N597
BS06 MG A D18 E516 D12 E499
BS07 MG A D18 H750 D12 H733
BS08 MG A R137 R139 R131 R133
BS09 MG A L197 N198 L191 N192
Gene Ontology
Molecular Function
GO:0003676 nucleic acid binding
GO:0003677 DNA binding
GO:0003723 RNA binding
GO:0004519 endonuclease activity
GO:0008270 zinc ion binding
GO:0046872 metal ion binding
Biological Process
GO:0051607 defense response to virus

View graph for
Molecular Function
View graph for
Biological Process
External links
PDB RCSB:8d2k, PDBe:8d2k, PDBj:8d2k
PDBsum8d2k
PubMed38348449
UniProtA0LWB3

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