Structure of PDB 8d22 Chain A

Receptor sequence
>8d22A (length=377) Species: 57270 (Plasmodium falciparum Palo Alto/Uganda) [Search protein sequence]
GPVIGIDLGTTYSCVGVFKNGRVEILNNELGNRITPSYVSFVDGERKVGE
AAKLEATLHPTQTVFDVKRLIGRKFDDQEVVKDRSLLPYEIVNNQGKPNI
KVQIKDKDTTFAPEQISAMVLEKMKEIAQSFLGKPVKNAVVTVPAYFNDA
QRQATKDAGTIAGLNIVRIINEPTAAALAYGLDKKEETSILVYDLGGGTF
DVSILVIDNGVFEVYATAGNTHLGGEDFDQRVMDYFIKMFKKKNNIDLRT
DKRAIQKLRKEVEIAKRNLSVVHSTQIEIEDIVEGHNFSETLTRAKFEEL
NDDLFRETLEPVKKVLDDAKYEKSKIDEIVLVGGSTRIPKIQQIIKEFFN
GKEPNRGINPDEAVAYGAAIQAGIILG
3D structure
PDB8d22 Targeting Plasmodium falciparum GRP78-NBD: nucleoside analogues as agents against the malaria chaperone
ChainA
Resolution2.0 Å
3D
structure
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Enzymatic activity
Enzyme Commision number ?
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 Q8L A G223 G224 G252 E290 K293 R294 S297 V298 G361 S362 R364 D388 G196 G197 G225 E263 K266 R267 S270 V271 G334 S335 R337 D361
Gene Ontology
Molecular Function
GO:0005524 ATP binding
GO:0140662 ATP-dependent protein folding chaperone

View graph for
Molecular Function
External links
PDB RCSB:8d22, PDBe:8d22, PDBj:8d22
PDBsum8d22
PubMed36275624
UniProtW4J0F1

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