Structure of PDB 8d19 Chain A

Receptor sequence
>8d19A (length=400) Species: 9606 (Homo sapiens) [Search protein sequence]
HMAQRAFPNPYADYNKSLAEGYFDAAGRLTPEFSQRLTNKIRELLQQMER
GLKSADPRDGTGYTGWAGIAVLYLHLYDVFGDPAYLQLAHGYVKQSLNCL
TKRSITFLCGDAGPLAVAAVLYHKMNNEKQAEDCITRLIHLNKIDPHAPN
EMLYGRIGYIYALLFVNKNFGVEKIPQSHIQQICETILTSGENLARKRNF
TAKSPLMYEWYQEYYVGAAHGLAGIYYYLMQPSLQVSQGKLHSLVKPSVD
YVCQLKFPSGNYPPCIGDNRDLLVHWCHGAPGVIYMLIQAYKVFREEKYL
CDAYQCADVIWQYGLLKKGYGLCHGSAGNAYAFLTLYNLTQDMKYLYRAC
KFAEWCLEYGEHGCRTPDTPFSLFEGMAGTIYFLADLLVPTKARFPAFEL
3D structure
PDB8d19 The mechanism of thia-Michael addition catalyzed by LanC enzymes.
ChainA
Resolution1.52 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 2.5.1.18: glutathione transferase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 ZN A C276 C322 H323 C277 C323 H324
BS02 GSH A R4 L272 H274 C276 K317 H323 R364 P366 D367 E374 R5 L273 H275 C277 K318 H324 R365 P367 D368 E375
Gene Ontology
Molecular Function
GO:0004364 glutathione transferase activity
GO:0004930 G protein-coupled receptor activity
GO:0005515 protein binding
GO:0008270 zinc ion binding
GO:0016740 transferase activity
GO:0017124 SH3 domain binding
GO:0043295 glutathione binding
GO:0046872 metal ion binding
GO:0050750 low-density lipoprotein particle receptor binding
Biological Process
GO:0005975 carbohydrate metabolic process
GO:0007186 G protein-coupled receptor signaling pathway
GO:0031179 peptide modification
GO:1990748 cellular detoxification
Cellular Component
GO:0005737 cytoplasm
GO:0005886 plasma membrane

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:8d19, PDBe:8d19, PDBj:8d19
PDBsum8d19
PubMed36634136
UniProtO43813|LANC1_HUMAN Glutathione S-transferase LANCL1 (Gene Name=LANCL1)

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