Structure of PDB 8d0q Chain A

Receptor sequence

>8d0qA (length=297) Species: 9606 (Homo sapiens)

ETTILVWVWPFGQTFDLTSCQAMFNIQGCHLTTDRSLYNKSHAVLIHHRD
ISWDLTNLPQQARPPFQKWIWMNLESPTHTPQKSGIEHLFNLTLTYRRDS
DIQVPYGFLTVSTNPFVFEVPSKEKLVCWVVSNWNPEHARVKYYNELSKS
IEIHTYGQAFGEYVNDKNLIPTISACKFYLSFENSIHKDYITEKLYNAFL
AGSVPVVLGPSRENYENYIPADSFIHVEDYNSPSELAKYLKEVDKNNKLY
LSYFNWRKDFTVNLPRFWESHACLACDHVKRHQEYKSVGNLEKWFWN

3D structure

• PDB: 8d0q Structural basis for Lewis antigen synthesis by the alpha 1,3-fucosyltransferase FUT9.
• Chain: A
• Resolution: 1.39 Å

Enzymatic activity

• Enzyme Commision number: 2.4.1.152: 4-galactosyl-N-acetylglucosaminide 3-alpha-L-fucosyltransferase.

Interaction with ligand

Site #	Ligand	Ligand chain	Binding residues on receptor (original residue number in PDB)	Binding residues on receptor (residue number reindexed from 1)	Binding affinity
BS01	GAL	A	F73 L136 E137 F329	F11 L74 E75 F267
BS02	GAL	A	F73 L136 E137 F329	F11 L74 E75 F267
BS03	6CK	A	E137 Y168 V192 V193 S194 N195 R202 Y225 V226 D228 N246 Y252 T254 E255 K256	E75 Y106 V130 V131 S132 N133 R140 Y163 V164 D166 N184 Y190 T192 E193 K194
BS04	GDP	A	V192 V193 S194 N195 R202 Y225 V226 N246 E255 K256	V130 V131 S132 N133 R140 Y163 V164 N184 E193 K194

Gene Ontology

Molecular Function

• GO:0008417 fucosyltransferase activity

Biological Process

• GO:0006486 protein glycosylation

Cellular Component

• GO:0016020 membrane

External links

• PDB: RCSB:8d0q, PDBe:8d0q, PDBj:8d0q
• PDBsum: 8d0q
• PubMed: 37202521
• UniProt: Q9Y231|FUT9_HUMAN 4-galactosyl-N-acetylglucosaminide 3-alpha-L-fucosyltransferase 9 (Gene Name=FUT9)