Structure of PDB 8czh Chain A

Receptor sequence
>8czhA (length=157) Species: 9606 (Homo sapiens) [Search protein sequence]
GSMSEEQVAQDTEEVFRSYVFYRHQQEQPADPEMVTLPLQPSSTMGQVGR
QLAIIGDDINRRYDSEFQTMLQHLQPTAENAYEYFTKIATSLFESGINWG
RVVALLGFGYRLALHVYQHGLTGFLGQVTRFVVDFMLHHSIARWIAQRGG
WVAALNL
3D structure
PDB8czh Peptides from human BNIP5 and PXT1 and non-native binders of pro-apoptotic BAK can directly activate or inhibit BAK-mediated membrane permeabilization.
ChainA
Resolution1.3 Å
3D
structure
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Enzymatic activity
Enzyme Commision number ?
Interaction with ligand
Site
#
Ligand Ligand
chain
Binding residues on receptor
(original residue number in PDB)
Binding residues on receptor
(residue number reindexed from 1)
Binding affinity
BS01 peptide A R88 Y89 E92 F93 M96 H99 L100 Y110 I114 S117 L118 N124 G126 F134 R62 Y63 E66 F67 M70 H73 L74 Y84 I88 S91 L92 N98 G100 F108
Gene Ontology
Biological Process
GO:0042981 regulation of apoptotic process

View graph for
Biological Process
External links
PDB RCSB:8czh, PDBe:8czh, PDBj:8czh
PDBsum8czh
PubMed36706751
UniProtQ16611|BAK_HUMAN Bcl-2 homologous antagonist/killer (Gene Name=BAK1)

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