Structure of PDB 8czg Chain A

Receptor sequence
>8czgA (length=157) Species: 9606 (Homo sapiens) [Search protein sequence]
SMSEEQVAQDTEEVFRSYVFYRHQQEQPADPEMVTLPLQPSSTMGQVGRQ
LAIIGDDINRRYDSEFQTMLQHLQPTAENAYEYFTKIATSLFESGINWGR
VVALLGFGYRLALHVYQHGLTGFLGQVTRFVVDFMLHHSIARWIAQRGGW
VAALNLG
3D structure
PDB8czg Peptides from human BNIP5 and PXT1 and non-native binders of pro-apoptotic BAK can directly activate or inhibit BAK-mediated membrane permeabilization.
ChainA
Resolution1.99 Å
3D
structure
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Enzymatic activity
Enzyme Commision number ?
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 peptide A I81 R88 Y89 F93 M96 H99 L100 Y110 I114 S117 L118 N124 W125 G126 R127 I54 R61 Y62 F66 M69 H72 L73 Y83 I87 S90 L91 N97 W98 G99 R100
Gene Ontology
Biological Process
GO:0042981 regulation of apoptotic process

View graph for
Biological Process
External links
PDB RCSB:8czg, PDBe:8czg, PDBj:8czg
PDBsum8czg
PubMed36706751
UniProtQ16611|BAK_HUMAN Bcl-2 homologous antagonist/killer (Gene Name=BAK1)

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