Structure of PDB 8cz9 Chain A

Receptor sequence
>8cz9A (length=108) Species: 10090 (Mus musculus) [Search protein sequence]
FLSCYPWFHGPISRVRAAQLVQLQGPDAHGVFLVRQSESRRGKYVLTFNL
QGRAKHLRLVLTERGQCRVQHLHFPSVVDMLRHFQRSPIPLECGAACDVR
LSGYVVVV
3D structure
PDB8cz9 Rare genetic variants in SH2B3 identified in lupus patients breach B cell tolerance and predispose carriers to autoimmunity
ChainA
Resolution1.65 Å
3D
structure
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Enzymatic activity
Enzyme Commision number ?
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 peptide A R343 R364 S366 E367 S368 V374 K384 H385 R387 Q399 H400 P419 L420 R14 R35 S37 E38 S39 V45 K55 H56 R58 Q70 H71 P90 L91
Gene Ontology
Molecular Function
GO:0035591 signaling adaptor activity
Biological Process
GO:0007165 signal transduction

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Molecular Function
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Biological Process
External links
PDB RCSB:8cz9, PDBe:8cz9, PDBj:8cz9
PDBsum8cz9
PubMed38417019
UniProtO09039|SH2B3_MOUSE SH2B adapter protein 3 (Gene Name=Sh2b3)

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